methyl 4-(ethylamino)-3-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)benzoate

Base Information

Chemical Name:methyl 4-(ethylamino)-3-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)benzoate
CAS No.:1081314-74-0
Molecular Formula:C₁₇H₂₅NO₅
Molecular Weight:323.389
Hs Code.:

Synonyms:methyl 4-(ethylamino)-3-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)benzoate

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Chemical Property of methyl 4-(ethylamino)-3-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)benzoate

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Technology Process of methyl 4-(ethylamino)-3-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)benzoate

There total 3 articles about methyl 4-(ethylamino)-3-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1081314-59-1
4-amino-3-[2-(tetrahydropyran-2-yloxy)ethoxy]benzoic acid methyl ester

: 75-07-0,9002-91-9
acetaldehyde

: 1081314-74-0
methyl 4-(ethylamino)-3-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)benzoate

: 1081314-66-0
C₁₉H₂₉NO₅

Guidance literature:: With sodium cyanoborohydride; acetic acid; In tetrahydrofuran; methanol; at 0 - 60 ℃;
DOI:10.1016/j.bmcl.2009.05.123

Reference yield:

: 1081314-59-1
4-amino-3-[2-(tetrahydropyran-2-yloxy)ethoxy]benzoic acid methyl ester

: 75-07-0,9002-91-9
acetaldehyde

: 1081314-74-0
methyl 4-(ethylamino)-3-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)benzoate

Guidance literature:: With sodium cyanoborohydride; acetic acid; In tetrahydrofuran; methanol; at 20 ℃; for 0.75h;

Reference yield:

: 713-52-0
methyl 3-hydroxy-4-nitrobenzoate

: 1081314-74-0
methyl 4-(ethylamino)-3-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 °C

2: palladium 10% on activated carbon / ethyl acetate / 7 h / 20 °C / Inert atmosphere

3: sodium cyanoborohydride; acetic acid / tetrahydrofuran; methanol / 0.75 h / 20 °C

With palladium 10% on activated carbon; sodium cyanoborohydride; potassium carbonate; acetic acid; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;