(2R,3R,4S)-2-{4-[4-((S)-2-Amino-3-methyl-butyrylamino)-butoxy]-benzylamino}-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid

Base Information

Chemical Name:(2R,3R,4S)-2-{4-[4-((S)-2-Amino-3-methyl-butyrylamino)-butoxy]-benzylamino}-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid
CAS No.:1053647-68-9
Molecular Formula:C₃₂H₄₈N₄O₇
Molecular Weight:600.756
Hs Code.:

Synonyms:(2R,3R,4S)-2-{4-[4-((S)-2-Amino-3-methyl-butyrylamino)-butoxy]-benzylamino}-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid

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Chemical Property of (2R,3R,4S)-2-{4-[4-((S)-2-Amino-3-methyl-butyrylamino)-butoxy]-benzylamino}-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid

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Technology Process of (2R,3R,4S)-2-{4-[4-((S)-2-Amino-3-methyl-butyrylamino)-butoxy]-benzylamino}-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid

There total 4 articles about (2R,3R,4S)-2-{4-[4-((S)-2-Amino-3-methyl-butyrylamino)-butoxy]-benzylamino}-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ((S)-1-{4-[4-(Hydroxyimino-methyl)-phenoxy]-butylcarbamoyl}-2-methyl-propyl)-carbamic acid benzyl ester

: 1053647-68-9
(2R,3R,4S)-2-{4-[4-((S)-2-Amino-3-methyl-butyrylamino)-butoxy]-benzylamino}-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: formic acid, H₂ / 10percent Pd/C / methanol / 3 h / 760 Torr

2: ethanol / 24 h / 80 °C

3: 0.4 M aq. LiOH / dioxane / 16 h / Ambient temperature

With lithium hydroxide; formic acid; hydrogen; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol;
DOI:10.1021/jm950641i

Reference yield:

: (2R,3R,4S)-2-{4-[4-((S)-2-Amino-3-methyl-butyrylamino)-butoxy]-benzylamino}-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid ethyl ester

: 1053647-68-9
(2R,3R,4S)-2-{4-[4-((S)-2-Amino-3-methyl-butyrylamino)-butoxy]-benzylamino}-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid

Guidance literature:: With lithium hydroxide; In 1,4-dioxane; for 16h; Ambient temperature;
DOI:10.1021/jm950641i

Reference yield:

: 1026612-94-1
(S)-2-Amino-N-[4-(4-aminomethyl-phenoxy)-butyl]-3-methyl-butyramide

: 1053647-68-9
(2R,3R,4S)-2-{4-[4-((S)-2-Amino-3-methyl-butyrylamino)-butoxy]-benzylamino}-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 24 h / 80 °C

2: 0.4 M aq. LiOH / dioxane / 16 h / Ambient temperature

With lithium hydroxide; In 1,4-dioxane; ethanol;
DOI:10.1021/jm950641i