rac-4-(1-(4-fluorophenyl)-6-methyl-1H-indazol-5-yl)-1-methyl-3-(pyridin-2-yl)-6,8-dihydro-1H-pyrazolo[3,4-e][1,4]thiazepin-7(4H)-one

Base Information

Chemical Name:rac-4-(1-(4-fluorophenyl)-6-methyl-1H-indazol-5-yl)-1-methyl-3-(pyridin-2-yl)-6,8-dihydro-1H-pyrazolo[3,4-e][1,4]thiazepin-7(4H)-one
CAS No.:1616361-43-3
Molecular Formula:C₂₆H₂₁FN₆OS
Molecular Weight:484.557
Hs Code.:

Synonyms:rac-4-(1-(4-fluorophenyl)-6-methyl-1H-indazol-5-yl)-1-methyl-3-(pyridin-2-yl)-6,8-dihydro-1H-pyrazolo[3,4-e][1,4]thiazepin-7(4H)-one

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Chemical Property of rac-4-(1-(4-fluorophenyl)-6-methyl-1H-indazol-5-yl)-1-methyl-3-(pyridin-2-yl)-6,8-dihydro-1H-pyrazolo[3,4-e][1,4]thiazepin-7(4H)-one

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Technology Process of rac-4-(1-(4-fluorophenyl)-6-methyl-1H-indazol-5-yl)-1-methyl-3-(pyridin-2-yl)-6,8-dihydro-1H-pyrazolo[3,4-e][1,4]thiazepin-7(4H)-one

There total 8 articles about rac-4-(1-(4-fluorophenyl)-6-methyl-1H-indazol-5-yl)-1-methyl-3-(pyridin-2-yl)-6,8-dihydro-1H-pyrazolo[3,4-e][1,4]thiazepin-7(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1616364-11-4
1-(4-fluorophenyl)-6-methyl-1H-indazole-5-carbaldehyde

: 68-11-1
mercaptoacetic acid

: 92406-50-3
1-methyl-3-(pyridin-2-yl)-1H-pyrazol-5-amine

: 1616361-43-3
rac-4-(1-(4-fluorophenyl)-6-methyl-1H-indazol-5-yl)-1-methyl-3-(pyridin-2-yl)-6,8-dihydro-1H-pyrazolo[3,4-e][1,4]thiazepin-7(4H)-one

Guidance literature:: With water; at 110 ℃; for 2h; Sealed tube;

Reference yield:

: 54123-21-6
3-(pyridine-2-yl)-3-oxopropanenitrile

: 1616361-43-3
rac-4-(1-(4-fluorophenyl)-6-methyl-1H-indazol-5-yl)-1-methyl-3-(pyridin-2-yl)-6,8-dihydro-1H-pyrazolo[3,4-e][1,4]thiazepin-7(4H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 18.5 h / 20 - 75 °C

2: water / 2 h / 110 °C / Sealed tube

With water; In ethanol;

Reference yield:

: 1765-93-1
4-fluoroboronic acid

: 1616361-43-3
rac-4-(1-(4-fluorophenyl)-6-methyl-1H-indazol-5-yl)-1-methyl-3-(pyridin-2-yl)-6,8-dihydro-1H-pyrazolo[3,4-e][1,4]thiazepin-7(4H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine; copper diacetate / dichloromethane / 4 h / Molecular sieve

2.1: palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / Microwave irradiation; Inert atmosphere

2.2: 24 h / 90 °C / Microwave irradiation; Sealed tube

3.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 4 h / 0 °C

4.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

5.1: water / 2 h / 110 °C / Sealed tube

With pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; water; copper diacetate; palladium diacetate; diisobutylaluminium hydride; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; toluene;