methyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-hydroxybenzoate

Base Information

Chemical Name:methyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-hydroxybenzoate
CAS No.:35019-69-3
Molecular Formula:C₁₆H₁₁NO₅
Molecular Weight:297.267
Hs Code.:
DSSTox Substance ID:DTXSID301163531

Synonyms:Oprea1_102095;Oprea1_167160;SCHEMBL1443688;DTXSID301163531;STK724083;AKOS000736719;SR-01000513660;SR-01000513660-1;Methyl 4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-2-hydroxybenzoate;methyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-hydroxybenzoate;35019-69-3

Suppliers and Price of methyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-hydroxybenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-hydroxybenzoate

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:297.06372245
Heavy Atom Count:22
Complexity:467

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C1=C(C=C(C=C1)N2C(=O)C3=CC=CC=C3C2=O)O

Technology Process of methyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-hydroxybenzoate

There total 3 articles about methyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-hydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 85-44-9
phthalic anhydride

: 4136-97-4
methyl 4-aminosalicylate

: 35019-69-3
4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-hydroxy-benzoic acid methyl ester

Guidance literature:: In acetic acid; at 118 ℃; for 22h; Inert atmosphere;
DOI:10.1039/c2ob26077h

Reference yield:

: 65-49-6
4-Aminosalicylic acid

: 35019-69-3
4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-hydroxy-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid / 22 °C

2: acetic acid / 22 h / 118 °C / Inert atmosphere

With sulfuric acid; In acetic acid;
DOI:10.1039/c2ob26077h