ethyl 2-((2-[(2R)-2-((1E,3S)-4-[3-(1-benzofuran-2-yl)phenyl]-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl) thio)-1,3-thiazole-4-carboxylate

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Chemical Name:ethyl 2-((2-[(2R)-2-((1E,3S)-4-[3-(1-benzofuran-2-yl)phenyl]-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl) thio)-1,3-thiazole-4-carboxylate
CAS No.:1380346-98-4
Molecular Formula:C₃₀H₃₀N₂O₅S₂
Molecular Weight:562.711
Hs Code.:

Synonyms:ethyl 2-((2-[(2R)-2-((1E,3S)-4-[3-(1-benzofuran-2-yl)phenyl]-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl) thio)-1,3-thiazole-4-carboxylate

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Chemical Property of ethyl 2-((2-[(2R)-2-((1E,3S)-4-[3-(1-benzofuran-2-yl)phenyl]-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl) thio)-1,3-thiazole-4-carboxylate

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Technology Process of ethyl 2-((2-[(2R)-2-((1E,3S)-4-[3-(1-benzofuran-2-yl)phenyl]-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl) thio)-1,3-thiazole-4-carboxylate

There total 10 articles about ethyl 2-((2-[(2R)-2-((1E,3S)-4-[3-(1-benzofuran-2-yl)phenyl]-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl) thio)-1,3-thiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₂H₃₄N₂O₆S₂

: 1380346-98-4
ethyl 2-((2-[(2R)-2-((1E,3S)-4-[3-(1-benzofuran-2-yl)phenyl]-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl) thio)-1,3-thiazole-4-carboxylate

Guidance literature:: With sodium tris(acetoxy)borohydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 20 ℃; for 15h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.04.008

Reference yield:

: C₂₉H₃₃NO₆

: 1380346-98-4
ethyl 2-((2-[(2R)-2-((1E,3S)-4-[3-(1-benzofuran-2-yl)phenyl]-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl) thio)-1,3-thiazole-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran; toluene / 1.08 h / 20 °C / Inert atmosphere

1.2: 0.08 h / 20 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane; ethanol / 6 h / 20 °C / Inert atmosphere

3.1: tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 50 °C / Inert atmosphere

4.1: sodium tris(acetoxy)borohydride / tetrahydrofuran; N,N-dimethyl-formamide / 15 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; borane-THF; sodium tris(acetoxy)borohydride; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2012.04.008

Reference yield:

: 597577-64-5
ethyl 2-[(2,2-diethoxyethyl)thio]-1,3-thiazole-4-carboxylate

: 1380346-98-4
ethyl 2-((2-[(2R)-2-((1E,3S)-4-[3-(1-benzofuran-2-yl)phenyl]-3-hydroxy-1-buten-1-yl)-5-oxo-1-pyrrolidinyl]ethyl) thio)-1,3-thiazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; water / acetonitrile / 16 h / 20 °C / Inert atmosphere

2: tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 50 °C / Inert atmosphere

3: sodium tris(acetoxy)borohydride / tetrahydrofuran; N,N-dimethyl-formamide / 15 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; water; sodium tris(acetoxy)borohydride; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2012.04.008