methyl 4-methyl-1-oxo-4-(2-oxo-2-p-tolylethyl)-3,3a,4,7a-tetrahydro-1H-furo[3,4-c]pyran-6-carboxylate

Base Information

Chemical Name:methyl 4-methyl-1-oxo-4-(2-oxo-2-p-tolylethyl)-3,3a,4,7a-tetrahydro-1H-furo[3,4-c]pyran-6-carboxylate
CAS No.:1459714-23-8
Molecular Formula:C₁₉H₂₀O₆
Molecular Weight:344.364
Hs Code.:

Synonyms:methyl 4-methyl-1-oxo-4-(2-oxo-2-p-tolylethyl)-3,3a,4,7a-tetrahydro-1H-furo[3,4-c]pyran-6-carboxylate

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Chemical Property of methyl 4-methyl-1-oxo-4-(2-oxo-2-p-tolylethyl)-3,3a,4,7a-tetrahydro-1H-furo[3,4-c]pyran-6-carboxylate

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Technology Process of methyl 4-methyl-1-oxo-4-(2-oxo-2-p-tolylethyl)-3,3a,4,7a-tetrahydro-1H-furo[3,4-c]pyran-6-carboxylate

There total 3 articles about methyl 4-methyl-1-oxo-4-(2-oxo-2-p-tolylethyl)-3,3a,4,7a-tetrahydro-1H-furo[3,4-c]pyran-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1459714-32-9
3-methylene-5-(p-tolyl)pent-4-yn-1-ol

: 38256-25-6
dimethyl (E)-2-oxoglutaconate

: 1459714-23-8
methyl 4-methyl-1-oxo-4-(2-oxo-2-p-tolylethyl)-3,3a,4,7a-tetrahydro-1H-furo[3,4-c]pyran-6-carboxylate

Guidance literature:: With C₃₂H₂₁O₄P; chloro(triphenylphosphine)silver(I); silver trifluoroacetate; In dichloromethane; at 25 ℃; for 24h;
DOI:10.1039/c3ob41611a

Reference yield:

: 1459714-32-9
3-methylene-5-(p-tolyl)pent-4-yn-1-ol

: 38256-25-6
dimethyl (E)-2-oxoglutaconate

: 1459714-23-8
methyl 4-methyl-1-oxo-4-(2-oxo-2-p-tolylethyl)-3,3a,4,7a-tetrahydro-1H-furo[3,4-c]pyran-6-carboxylate

: methyl 4-methyl-1-oxo-4-(2-oxo-2-p-tolylethyl)-3,3a,4,7a-tetrahydro-1H-furo[3,4-c]pyran-6-carboxylate

Guidance literature:: With copper(II) hexafluoroantimonate; chloro(triphenylphosphine)silver(I); silver trifluoroacetate; {3aS-[2(3'aR*,8'aS*),3aα,8aα]}-2,2'-(cyclopropylidene)-bis{3a,8a-dihydro-8H-indeno[1,2-d]-oxazole}; In dichloromethane; at 25 ℃; for 24h; Overall yield = 51 %; enantioselective reaction;
DOI:10.1039/c3ob41611a

Reference yield:

: 766-97-2
4-n-methylphenylacetylene

: 1459714-23-8
methyl 4-methyl-1-oxo-4-(2-oxo-2-p-tolylethyl)-3,3a,4,7a-tetrahydro-1H-furo[3,4-c]pyran-6-carboxylate

: methyl 4-methyl-1-oxo-4-(2-oxo-2-p-tolylethyl)-3,3a,4,7a-tetrahydro-1H-furo[3,4-c]pyran-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; triethylamine; copper(l) iodide / 12 h / 20 - 60 °C / Inert atmosphere

2: chloro(triphenylphosphine)silver(I); silver trifluoroacetate; copper(II) hexafluoroantimonate; {3aS-[2(3'aR*,8'aS*),3aα,8aα]}-2,2'-(cyclopropylidene)-bis{3a,8a-dihydro-8H-indeno[1,2-d]-oxazole} / dichloromethane / 24 h / 25 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; copper(II) hexafluoroantimonate; chloro(triphenylphosphine)silver(I); silver trifluoroacetate; triethylamine; {3aS-[2(3'aR*,8'aS*),3aα,8aα]}-2,2'-(cyclopropylidene)-bis{3a,8a-dihydro-8H-indeno[1,2-d]-oxazole}; In dichloromethane; 2: |Diels-Alder Cycloaddition;
DOI:10.1039/c3ob41611a