(2R)-3-[4-((2S)-2-{(2S)-2-[2-((2S)-2-[((2S)-1-acetylpyrrolidin-2-yl)carbonylamino]-N-{4-[(tert-butoxy)carbonylamino]butyl}-4-methylpentanoylamino)acetylamino]-4-phenylbutanoylamino}-4-methylpentanoylamino)phenyl]-2-[(tert-butoxy)carbonylamino]propanoic acid

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Chemical Name:(2R)-3-[4-((2S)-2-{(2S)-2-[2-((2S)-2-[((2S)-1-acetylpyrrolidin-2-yl)carbonylamino]-N-{4-[(tert-butoxy)carbonylamino]butyl}-4-methylpentanoylamino)acetylamino]-4-phenylbutanoylamino}-4-methylpentanoylamino)phenyl]-2-[(tert-butoxy)carbonylamino]propanoic acid
CAS No.:919529-28-5
Molecular Formula:C₅₄H₈₂N₈O₁₂
Molecular Weight:1035.29
Hs Code.:

(2R)-3-[4-((2S)-2-{(2S)-2-[2-((2S)-2-[((2S)-1-acetylpyrrolidin-2-yl)carbonylamino]-N-{4-[(tert-butoxy)carbonylamino]butyl}-4-methylpentanoylamino)acetylamino]-4-phenylbutanoylamino}-4-methylpentanoylamino)phenyl]-2-[(tert-butoxy)carbonylamino]propanoic acid

Synonyms:(2R)-3-[4-((2S)-2-{(2S)-2-[2-((2S)-2-[((2S)-1-acetylpyrrolidin-2-yl)carbonylamino]-N-{4-[(tert-butoxy)carbonylamino]butyl}-4-methylpentanoylamino)acetylamino]-4-phenylbutanoylamino}-4-methylpentanoylamino)phenyl]-2-[(tert-butoxy)carbonylamino]propanoic acid

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Chemical Property of (2R)-3-[4-((2S)-2-{(2S)-2-[2-((2S)-2-[((2S)-1-acetylpyrrolidin-2-yl)carbonylamino]-N-{4-[(tert-butoxy)carbonylamino]butyl}-4-methylpentanoylamino)acetylamino]-4-phenylbutanoylamino}-4-methylpentanoylamino)phenyl]-2-[(tert-butoxy)carbonylamino]propanoic acid

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Technology Process of (2R)-3-[4-((2S)-2-{(2S)-2-[2-((2S)-2-[((2S)-1-acetylpyrrolidin-2-yl)carbonylamino]-N-{4-[(tert-butoxy)carbonylamino]butyl}-4-methylpentanoylamino)acetylamino]-4-phenylbutanoylamino}-4-methylpentanoylamino)phenyl]-2-[(tert-butoxy)carbonylamino]propanoic acid

There total 1 articles about (2R)-3-[4-((2S)-2-{(2S)-2-[2-((2S)-2-[((2S)-1-acetylpyrrolidin-2-yl)carbonylamino]-N-{4-[(tert-butoxy)carbonylamino]butyl}-4-methylpentanoylamino)acetylamino]-4-phenylbutanoylamino}-4-methylpentanoylamino)phenyl]-2-[(tert-butoxy)carbonylamino]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.9%

: 1201666-18-3
Boc-DPhe(4-NH₂)-OH TFA

: 919529-26-3
Ac-PL-NLys(Boc)-Hphe-L-OH

: 919529-28-5
(2R)-3-[4-((2S)-2-{(2S)-2-[2-((2S)-2-[((2S)-1-acetylpyrrolidin-2-yl)carbonylamino]-N-{4-[(tert-butoxy)carbonylamino]butyl}-4-methylpentanoylamino)acetylamino]-4-phenylbutanoylamino}-4-methylpentanoylamino)phenyl]-2-[(tert-butoxy)carbonylamino]propanoic acid

Guidance literature:: With HBTU; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 22 ℃; for 6h;

Reference yield: 51.6%

: 919527-90-5
N-amino-6-[(fluoren-9-ylmethoxy)carbonylamino]hexanamide trifluoroacetic acid salt

: 919529-28-5
(2R)-3-[4-((2S)-2-{(2S)-2-[2-((2S)-2-[((2S)-1-acetylpyrrolidin-2-yl)carbonylamino]-N-{4-[(tert-butoxy)carbonylamino]butyl}-4-methylpentanoylamino)acetylamino]-4-phenylbutanoylamino}-4-methylpentanoylamino)phenyl]-2-[(tert-butoxy)carbonylamino]propanoic acid

: 76-05-1
trifluoroacetic acid

: N-{(2R)-3-[4-((2S)-2-{(2S)-2-[2-((2S)-2-[((2S)-1-acetylpyrrolidin-2-yl)carbonylamino]-N-{4-[(tert-butoxy)carbonylamino]butyl}-4-methylpentanoylamino)-acetylamino]-4-phenylbutanoylamino}-4-methylpentanoylamino)phenyl]-2-[(tert-butoxy)carbonylamino]propanoylamino}-6-aminohexanamide trifluoroacetic acid salt

Guidance literature:: (2R)-3-[4-((2S)-2-{(2S)-2-[2-((2S)-2-[((2S)-1-acetylpyrrolidin-2-yl)carbonylamino]-N-{4-[(tert-butoxy)carbonylamino]butyl}-4-methylpentanoylamino)acetylamino]-4-phenylbutanoylamino}-4-methylpentanoylamino)phenyl]-2-[(tert-butoxy)carbonylamino]propanoic acid; With 2,3,4-lutidine; 1-hydroxy-7-aza-benzotriazole; diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at 22 ℃; for 0.0833333h;

N-amino-6-[(fluoren-9-ylmethoxy)carbonylamino]hexanamide trifluoroacetic acid salt; With diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at 22 ℃; for 22h;

trifluoroacetic acid; With piperidine; more than 3 stages;