1,1-dimethylethyl 4-{3-chloro-5-[(ethyloxy)carbonyl]phenyl}-3,6-dihydro-1(2H)-pyridinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl 4-{3-chloro-5-[(ethyloxy)carbonyl]phenyl}-3,6-dihydro-1(2H)-pyridinecarboxylate
CAS No.:1095274-69-3
Molecular Formula:C₁₉H₂₄ClNO₄
Molecular Weight:365.857
Hs Code.:

Synonyms:1,1-dimethylethyl 4-{3-chloro-5-[(ethyloxy)carbonyl]phenyl}-3,6-dihydro-1(2H)-pyridinecarboxylate

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Chemical Property of 1,1-dimethylethyl 4-{3-chloro-5-[(ethyloxy)carbonyl]phenyl}-3,6-dihydro-1(2H)-pyridinecarboxylate

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Technology Process of 1,1-dimethylethyl 4-{3-chloro-5-[(ethyloxy)carbonyl]phenyl}-3,6-dihydro-1(2H)-pyridinecarboxylate

There total 4 articles about 1,1-dimethylethyl 4-{3-chloro-5-[(ethyloxy)carbonyl]phenyl}-3,6-dihydro-1(2H)-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1095274-55-7
3-bromo-5-chlorobenzoic acid ethyl ester

: 375853-82-0,286961-14-6
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 1095274-69-3
1,1-dimethylethyl 4-{3-chloro-5-[(ethyloxy)carbonyl]phenyl}-3,6-dihydro-1(2H)-pyridinecarboxylate

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 100 - 120 ℃; for 0.666667h; Microwave irradition;

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1095274-69-3
1,1-dimethylethyl 4-{3-chloro-5-[(ethyloxy)carbonyl]phenyl}-3,6-dihydro-1(2H)-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.25 h / -78 °C

1.2: 2 h / -78 - 20 °C

2.1: potassium acetate / 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 18 h / 80 °C

3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.67 h / 100 - 120 °C / Microwave irradition

With n-butyllithium; potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 42860-02-6
3‐bromo‐5‐chlorobenzoic acid

: 1095274-69-3
1,1-dimethylethyl 4-{3-chloro-5-[(ethyloxy)carbonyl]phenyl}-3,6-dihydro-1(2H)-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid / 1 h / Heating / reflux

2: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.67 h / 100 - 120 °C / Microwave irradition

With sulfuric acid; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water;