1-(uracil-1-yl)-2-O-benzoyl-3-O-(diisopropylphosphonomethyl)-L-threose

Base Information

• Chemical Name: 1-(uracil-1-yl)-2-O-benzoyl-3-O-(diisopropylphosphonomethyl)-L-threose
• CAS No.: 849778-79-6
• Molecular Formula: C₂₂H₂₉N₂O₉P
• Molecular Weight: 496.454
• Mol file: 849778-79-6.mol

Synonyms:1-(uracil-1-yl)-2-O-benzoyl-3-O-(diisopropylphosphonomethyl)-L-threose

Chemical Property of 1-(uracil-1-yl)-2-O-benzoyl-3-O-(diisopropylphosphonomethyl)-L-threose

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(uracil-1-yl)-2-O-benzoyl-3-O-(diisopropylphosphonomethyl)-L-threose

There total 2 articles about 1-(uracil-1-yl)-2-O-benzoyl-3-O-(diisopropylphosphonomethyl)-L-threose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

C25H31O9P + O,O'-bis-(trimethylsilyl)uracil (10457-14-4) → 1-(uracil-1-yl)-2-O-benzoyl-3-O-(diisopropylphosphonomethyl)-L-threose (849778-79-6)

Guidance literature:

With tin(IV) chloride; In acetonitrile; at 20 ℃; for 4h;

DOI:10.1021/ja043045z

Reference yield: 84.0%

1α,2-O-benzoyl-3-O-(diisopropylphosphonomethyl)-L-threose (849779-01-7) + uracil (66-22-8,144104-68-7,18324-22-6,27072-01-1,2920-92-5,51953-19-6) → 1-(uracil-1-yl)-2-O-benzoyl-3-O-(diisopropylphosphonomethyl)-L-threose (849778-79-6)

Guidance literature:

uracil; With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane; Heating / reflux;

1α,2-O-benzoyl-3-O-(diisopropylphosphonomethyl)-L-threose; With tin(IV) chloride; In acetonitrile; for 4h;

Reference yield:

1-(uracil-1-yl)-2-O-benzoyl-3-O-(diisopropylphosphonomethyl)-L-threose (849778-79-6) → 1-(uracil-1-yl)-2-O-phenoxythiocarbonyl-3-(diisopropylphosphonomethyl)-L-threose

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / ammonia / methanol / 20 °C

2: DMAP / acetonitrile / 12 h / 20 °C

With ammonia; dmap; In methanol; acetonitrile;

DOI:10.1021/ja043045z

upstream raw materials:

O,O'-bis-(trimethylsilyl)uracil

1α,2-O-benzoyl-3-O-(diisopropylphosphonomethyl)-L-threose

uracil