N-(4-chloro-5-(4-(4-(2-methoxyphenyl)-1-methyl-1H-1,2,3-triazole-5-carbonyl)piperazin-1-yl)-2-nitrophenyl)-4-((dimethylamino)methyl)benzamide

Base Information

Chemical Name:N-(4-chloro-5-(4-(4-(2-methoxyphenyl)-1-methyl-1H-1,2,3-triazole-5-carbonyl)piperazin-1-yl)-2-nitrophenyl)-4-((dimethylamino)methyl)benzamide
CAS No.:1364523-27-2
Molecular Formula:C₃₁H₃₃ClN₈O₅
Molecular Weight:633.107
Hs Code.:

Synonyms:N-(4-chloro-5-(4-(4-(2-methoxyphenyl)-1-methyl-1H-1,2,3-triazole-5-carbonyl)piperazin-1-yl)-2-nitrophenyl)-4-((dimethylamino)methyl)benzamide

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Chemical Property of N-(4-chloro-5-(4-(4-(2-methoxyphenyl)-1-methyl-1H-1,2,3-triazole-5-carbonyl)piperazin-1-yl)-2-nitrophenyl)-4-((dimethylamino)methyl)benzamide

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Technology Process of N-(4-chloro-5-(4-(4-(2-methoxyphenyl)-1-methyl-1H-1,2,3-triazole-5-carbonyl)piperazin-1-yl)-2-nitrophenyl)-4-((dimethylamino)methyl)benzamide

There total 7 articles about N-(4-chloro-5-(4-(4-(2-methoxyphenyl)-1-methyl-1H-1,2,3-triazole-5-carbonyl)piperazin-1-yl)-2-nitrophenyl)-4-((dimethylamino)methyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1364523-68-1
1-methyl-4-(2-methoxyphenyl)-[1,2,3]triazole-5-carboxylic acid

: 1364524-25-3
N-(4-chloro-2-nitro-5-(piperazin-1-yl)phenyl)-4-((dimethylamino)methyl)benzamide

: 1364523-27-2
N-(4-chloro-5-(4-(4-(2-methoxyphenyl)-1-methyl-1H-1,2,3-triazole-5-carbonyl)piperazin-1-yl)-2-nitrophenyl)-4-((dimethylamino)methyl)benzamide

Guidance literature:: With dmap; HATU; In 1-methyl-pyrrolidin-2-one; for 3h;

Reference yield:

: 4-chloro-2-nitro-5-(piperazin-1-yl)aniline

: 1364523-27-2
N-(4-chloro-5-(4-(4-(2-methoxyphenyl)-1-methyl-1H-1,2,3-triazole-5-carbonyl)piperazin-1-yl)-2-nitrophenyl)-4-((dimethylamino)methyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 2 h

2.1: dmap; 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine / acetonitrile / 80 °C

2.2: 2 h

3.1: trifluoroacetic acid / dichloromethane / 1 h

4.1: dmap; HATU / 1-methyl-pyrrolidin-2-one / 3 h

With dmap; 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; triethylamine; HATU; trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; dichloromethane; acetonitrile;

Reference yield:

: 529-28-2
4-iodoanisol

: 1364523-27-2
N-(4-chloro-5-(4-(4-(2-methoxyphenyl)-1-methyl-1H-1,2,3-triazole-5-carbonyl)piperazin-1-yl)-2-nitrophenyl)-4-((dimethylamino)methyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(I) oxide / N,N-dimethyl-formamide / 2 h / 110 °C / Microwave irradiation

2.1: sodium azide / N,N-dimethyl-formamide; water / 6 h / 100 °C / Microwave irradiation

3.1: sodium hydroxide; water / methanol / 2 h / 20 °C

3.2: pH 3

4.1: dmap; HATU / 1-methyl-pyrrolidin-2-one / 3 h

With copper(I) oxide; dmap; sodium azide; water; HATU; sodium hydroxide; In 1-methyl-pyrrolidin-2-one; methanol; water; N,N-dimethyl-formamide;