3,4-dihydroxy-N-[1-[2-(5-hydroxy-1H-indol-3-yl)-2-oxoethyl]piperidin-4-yl]benzamide

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Chemical Name:3,4-dihydroxy-N-[1-[2-(5-hydroxy-1H-indol-3-yl)-2-oxoethyl]piperidin-4-yl]benzamide
CAS No.:1446498-70-9
Molecular Formula:C₂₂H₂₃N₃O₅
Molecular Weight:409.442
Hs Code.:

Synonyms:3,4-dihydroxy-N-[1-[2-(5-hydroxy-1H-indol-3-yl)-2-oxoethyl]piperidin-4-yl]benzamide

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Chemical Property of 3,4-dihydroxy-N-[1-[2-(5-hydroxy-1H-indol-3-yl)-2-oxoethyl]piperidin-4-yl]benzamide

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Technology Process of 3,4-dihydroxy-N-[1-[2-(5-hydroxy-1H-indol-3-yl)-2-oxoethyl]piperidin-4-yl]benzamide

There total 7 articles about 3,4-dihydroxy-N-[1-[2-(5-hydroxy-1H-indol-3-yl)-2-oxoethyl]piperidin-4-yl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1446498-68-5
3,4-bis(benzyloxy)-N-(1-(2-(5-(benzyloxy)-1H-indol-3-yl)-2-oxoethyl)piperidin-4-yl)benzamide

: 1446498-70-9
3,4-dihydroxy-N-[1-[2-(5-hydroxy-1H-indol-3-yl)-2-oxoethyl]piperidin-4-yl]benzamide

Guidance literature:: With boron tribromide; In dichloromethane; at 20 ℃; for 10h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.05.044

Reference yield:

: 1215-59-4
5-benzyloxy-1H-indole

: 1446498-70-9
3,4-dihydroxy-N-[1-[2-(5-hydroxy-1H-indol-3-yl)-2-oxoethyl]piperidin-4-yl]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; toluene / 1.5 h / 60 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 80 °C

3: boron tribromide / dichloromethane / 10 h / 20 °C / Inert atmosphere

With boron tribromide; N-ethyl-N,N-diisopropylamine; In pyridine; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2013.05.044

Reference yield:

: 1570-05-4
3,4-bis(benzyloxy)benzoic acid

: 1446498-70-9
3,4-dihydroxy-N-[1-[2-(5-hydroxy-1H-indol-3-yl)-2-oxoethyl]piperidin-4-yl]benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; triethylamine; 1,2-dichloro-ethane; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 80 °C

4: boron tribromide / dichloromethane / 10 h / 20 °C / Inert atmosphere

With dmap; boron tribromide; benzotriazol-1-ol; 1,2-dichloro-ethane; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.05.044