(2-butyl-5-nitro-benzofuran-3-yl)-[4-(3-di-[²H₉]-butylamino-propoxy)-phenyl]-methanone

Base Information

• Chemical Name: (2-butyl-5-nitro-benzofuran-3-yl)-[4-(3-di-[²H₉]-butylamino-propoxy)-phenyl]-methanone
• CAS No.: 1542232-42-7
• Molecular Formula: C₃₀H₄₀N₂O₅
• Molecular Weight: 526.515

Synonyms:(2-butyl-5-nitro-benzofuran-3-yl)-[4-(3-di-[²H₉]-butylamino-propoxy)-phenyl]-methanone

Chemical Property of (2-butyl-5-nitro-benzofuran-3-yl)-[4-(3-di-[²H₉]-butylamino-propoxy)-phenyl]-methanone

Chemical Property:

Purity/Quality:

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Technology Process of (2-butyl-5-nitro-benzofuran-3-yl)-[4-(3-di-[²H₉]-butylamino-propoxy)-phenyl]-methanone

There total 2 articles about (2-butyl-5-nitro-benzofuran-3-yl)-[4-(3-di-[²H₉]-butylamino-propoxy)-phenyl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

[4-(3-bromo-propoxy)-phenyl]-(2-butyl-5-nitro-benzofuran-3-yl)-methanone (141645-38-7) + [2H18]-dibutylamine (203578-32-9) → (2-butyl-5-nitro-benzofuran-3-yl)-[4-(3-di-[2H9]-butylamino-propoxy)-phenyl]-methanone (1542232-42-7)

Guidance literature:

In ethanol; Reflux;

DOI:10.1002/jlcr.3090

Reference yield:

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran (141645-16-1) → (2-butyl-5-nitro-benzofuran-3-yl)-[4-(3-di-[2H9]-butylamino-propoxy)-phenyl]-methanone (1542232-42-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / neat (no solvent) / 5 h / Reflux

2: ethanol / Reflux

With sodium hydroxide; In ethanol;

DOI:10.1002/jlcr.3090

Reference yield: 90.0%

(2-butyl-5-nitro-benzofuran-3-yl)-[4-(3-di-[2H9]-butylamino-propoxy)-phenyl]-methanone (1542232-42-7) → (5-amino-2-butyl-benzofuran-3-yl)-[4-(3-di-[2H9]-butylaminopropoxy)-phenyl]-methanone (1542232-50-7)

Guidance literature:

With tin(II) chloride dihdyrate; In ethanol; at 80 ℃; Inert atmosphere;

DOI:10.1002/jlcr.3090

upstream raw materials:

[4-(3-bromo-propoxy)-phenyl]-(2-butyl-5-nitro-benzofuran-3-yl)-methanone

[²H₁₈]-dibutylamine

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Downstream raw materials:

(5-amino-2-butyl-benzofuran-3-yl)-[4-(3-di-[²H₉]-butylaminopropoxy)-phenyl]-methanone

N-{2-butyl-3-[4-(3-di-[²H₉]-butylamino-propoxy)-benzoyl]-benzofuran-5-yl}-methanesulfonamide hydrochloride

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