tert-butyl 2-phenyl-2-[N-(p-methoxyphenyl)amino]-3,3,3-trifluoropropanoate

Base Information

• Chemical Name: tert-butyl 2-phenyl-2-[N-(p-methoxyphenyl)amino]-3,3,3-trifluoropropanoate
• CAS No.: 278611-79-3
• Molecular Formula: C₂₀H₂₂F₃NO₃
• Molecular Weight: 381.395
• Mol file: 278611-79-3.mol

Synonyms:tert-butyl 2-phenyl-2-[N-(p-methoxyphenyl)amino]-3,3,3-trifluoropropanoate

Chemical Property of tert-butyl 2-phenyl-2-[N-(p-methoxyphenyl)amino]-3,3,3-trifluoropropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2-phenyl-2-[N-(p-methoxyphenyl)amino]-3,3,3-trifluoropropanoate

There total 1 articles about tert-butyl 2-phenyl-2-[N-(p-methoxyphenyl)amino]-3,3,3-trifluoropropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

phenyllithium (591-51-5) + tert-butyl 2-[N-(p-methoxyphenyl)imino]-3,3,3-trifluoropropanoate (278611-73-7) → tert-butyl 2-phenyl-2-[N-(p-methoxyphenyl)amino]-3,3,3-trifluoropropanoate (278611-79-3)

Guidance literature:

In tetrahydrofuran; at -78 ℃; for 0.0833333h;

DOI:10.1021/jo991917n

Reference yield: 96.0%

tert-butyl 2-phenyl-2-[N-(p-methoxyphenyl)amino]-3,3,3-trifluoropropanoate (278611-79-3) → 2-amino-3,3,3-trifluoro-2-phenyl-propionic acid tert-butyl ester

Guidance literature:

With ammonium cerium(IV) nitrate; In acetonitrile; at 20 ℃;

DOI:10.1021/jo991917n

Reference yield:

tert-butyl 2-phenyl-2-[N-(p-methoxyphenyl)amino]-3,3,3-trifluoropropanoate (278611-79-3) → 2-amino-2-phenyl-3,3,3-trifluoropropanoic acid hydrochloride

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / CAN / acetonitrile / 20 °C

2: 99 percent / aq. HCl / methanol / 12 h / 20 °C

With hydrogenchloride; ammonium cerium(IV) nitrate; In methanol; acetonitrile; 1: oxidative deprotection / 2: Hydrolysis;

DOI:10.1021/jo991917n

upstream raw materials:

phenyllithium

tert-butyl 2-[N-(p-methoxyphenyl)imino]-3,3,3-trifluoropropanoate