Technology Process of tert-butyl N-(diphenylmethylene)-O-isopropyl-2-nitro-L-tyrosinate
There total 5 articles about tert-butyl N-(diphenylmethylene)-O-isopropyl-2-nitro-L-tyrosinate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
cesium hydroxide; (2S,4S,5R)-1-(anthracen-9-ylmethyl)-5-ethenyl-2-[(R)-(prop-2-en-1-yloxy)(quinolin-4-yl)methyl]-1-azabicyclo[2.2.2]octan-1-ium bromide;
In
dichloromethane;
at -30 ℃;
for 18h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: potassium carbonate / N,N-dimethyl-formamide / 18 h
2: lithium hydroxide / tetrahydrofuran; methanol / 3 h / 20 °C
3: borane-THF / tetrahydrofuran / 18 h / 50 °C
4: phosphorus tribromide / diethyl ether / 5.5 h / 0 - 20 °C
5: cesium hydroxide; (2S,4S,5R)-1-(anthracen-9-ylmethyl)-5-ethenyl-2-[(R)-(prop-2-en-1-yloxy)(quinolin-4-yl)methyl]-1-azabicyclo[2.2.2]octan-1-ium bromide / dichloromethane / 18 h / -30 °C
With
borane-THF; cesium hydroxide; phosphorus tribromide; potassium carbonate; (2S,4S,5R)-1-(anthracen-9-ylmethyl)-5-ethenyl-2-[(R)-(prop-2-en-1-yloxy)(quinolin-4-yl)methyl]-1-azabicyclo[2.2.2]octan-1-ium bromide; lithium hydroxide;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: lithium hydroxide / tetrahydrofuran; methanol / 3 h / 20 °C
2: borane-THF / tetrahydrofuran / 18 h / 50 °C
3: phosphorus tribromide / diethyl ether / 5.5 h / 0 - 20 °C
4: cesium hydroxide; (2S,4S,5R)-1-(anthracen-9-ylmethyl)-5-ethenyl-2-[(R)-(prop-2-en-1-yloxy)(quinolin-4-yl)methyl]-1-azabicyclo[2.2.2]octan-1-ium bromide / dichloromethane / 18 h / -30 °C
With
borane-THF; cesium hydroxide; phosphorus tribromide; (2S,4S,5R)-1-(anthracen-9-ylmethyl)-5-ethenyl-2-[(R)-(prop-2-en-1-yloxy)(quinolin-4-yl)methyl]-1-azabicyclo[2.2.2]octan-1-ium bromide; lithium hydroxide;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane;
