C₂₁H₁₆F₄O₄

Base Information

• Chemical Name: C₂₁H₁₆F₄O₄
• CAS No.: 1333327-28-8
• Molecular Formula: C₂₁H₁₆F₄O₄
• Molecular Weight: 408.349
• Mol file: 1333327-28-8.mol

Synonyms:C₂₁H₁₆F₄O₄

Chemical Property of C₂₁H₁₆F₄O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₁₆F₄O₄

There total 5 articles about C₂₁H₁₆F₄O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

4-vinyl-2,3,5,6-tetrafluorobenzylalcohol (139183-76-9) + C12H12O4 (324740-20-7) → C21H16F4O4 (1333327-28-8)

Guidance literature:

C₁₂H₁₂O₄; With oxalyl dichloride; In dichloromethane; at 20 ℃;

4-vinyl-2,3,5,6-tetrafluorobenzylalcohol; With dmap; triethylamine; In dichloromethane; at 0 ℃;

With hydrogenchloride; In dichloromethane; water;

DOI:10.1016/j.jfluchem.2011.07.021

Reference yield:

4-vinyl-benzaldehyde (1791-26-0) → C21H16F4O4 (1333327-28-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dmap; triethylamine / dichloromethane / 0 - 20 °C

2.1: oxalyl dichloride / dichloromethane / 20 °C

2.2: 0 °C

With dmap; oxalyl dichloride; triethylamine; In dichloromethane;

DOI:10.1016/j.jfluchem.2011.07.021

Reference yield:

C9H4F4O (1333327-25-5) → C21H16F4O4 (1333327-28-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / methanol / 20 °C / Cooling with ice

2.1: oxalyl dichloride / dichloromethane / 20 °C

2.2: 0 °C

With sodium tetrahydroborate; oxalyl dichloride; In methanol; dichloromethane;

DOI:10.1016/j.jfluchem.2011.07.021

upstream raw materials:

C₁₁H₈F₄O₂

C₉H₄F₄O

4-vinyl-2,3,5,6-tetrafluorobenzylalcohol

C₁₂H₁₂O₄

Downstream raw materials:

C₂₅H₂₄F₄O₄