Technology Process of {2,5-Dimethyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetic acid
There total 15 articles about {2,5-Dimethyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Ethyl 2-(2,5-dimethyl-4-oxo-3-(2-(phenylsulfonyl)benzyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1-yl)acetate;
With
lithium hydroxide monohydrate; water;
In
tetrahydrofuran;
at 20 ℃;
for 1h;
With
hydrogenchloride;
In
water;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: potassium carbonate / dimethyl sulfoxide / 4 h / 100 °C
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C
3.1: toluene / 90 °C
4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 50 °C
5.1: dimethyl sulfoxide; trimethylsilyl bromide / acetonitrile / 2 h / 20 °C
6.1: ammonium acetate / ethanol / 15 h / 20 °C
7.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C
8.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C
9.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C
9.2: -78 - 20 °C
10.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 1 h / 20 °C
With
lithium hydroxide monohydrate; trimethylsilyl bromide; ammonium acetate; water; hydrogen; sodium hydride; potassium carbonate; dimethyl sulfoxide; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; lithium hexamethyldisilazane;
palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: potassium carbonate / dimethyl sulfoxide / 4 h / 100 °C
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C
3.1: toluene / 90 °C
4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 50 °C
5.1: dimethyl sulfoxide; trimethylsilyl bromide / acetonitrile / 2 h / 20 °C
6.1: ammonium acetate / ethanol / 15 h / 20 °C
7.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C
8.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C
9.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C
9.2: -78 - 20 °C
10.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 1 h / 20 °C
With
lithium hydroxide monohydrate; trimethylsilyl bromide; ammonium acetate; water; hydrogen; sodium hydride; potassium carbonate; dimethyl sulfoxide; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; lithium hexamethyldisilazane;
palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;
![Ethyl 2-(2,5-dimethyl-4-oxo-3-(2-(phenylsulfonyl)benzyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1-yl)acetate](/Databaselist/images/loading.webp)
