6-benzoyl-5-(benzyloxy)-1,2-dihydro-8-methyl-3-(phenylsulfonyl)-1-vinyl-3H-pyrrolo<3,2-e>indole

Base Information

Chemical Name:6-benzoyl-5-(benzyloxy)-1,2-dihydro-8-methyl-3-(phenylsulfonyl)-1-vinyl-3H-pyrrolo<3,2-e>indole
CAS No.:114996-69-9
Molecular Formula:C₃₃H₂₈N₂O₄S
Molecular Weight:548.662
Hs Code.:

Synonyms:6-benzoyl-5-(benzyloxy)-1,2-dihydro-8-methyl-3-(phenylsulfonyl)-1-vinyl-3H-pyrrolo<3,2-e>indole

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Chemical Property of 6-benzoyl-5-(benzyloxy)-1,2-dihydro-8-methyl-3-(phenylsulfonyl)-1-vinyl-3H-pyrrolo<3,2-e>indole

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Technology Process of 6-benzoyl-5-(benzyloxy)-1,2-dihydro-8-methyl-3-(phenylsulfonyl)-1-vinyl-3H-pyrrolo<3,2-e>indole

There total 12 articles about 6-benzoyl-5-(benzyloxy)-1,2-dihydro-8-methyl-3-(phenylsulfonyl)-1-vinyl-3H-pyrrolo<3,2-e>indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1-benzoyl-7-(benzyloxy)-4-bromo-3-methyl-N⁵-(phenylsulfonyl)-5<(4-(phenylthio)-2-buten-1-yl)amino>indole

: 114996-69-9
6-benzoyl-5-(benzyloxy)-1,2-dihydro-8-methyl-3-(phenylsulfonyl)-1-vinyl-3H-pyrrolo<3,2-e>indole

Guidance literature:: With tri-n-butyl-tin hydride; 2,2'-azobis(isobutyronitrile); In benzene; for 2.5h; Heating;
DOI:10.1021/ja00222a043

Reference yield:

: 38880-89-6
N-(2-hydroxy-4-nitrophenyl)benzamide

: 114996-69-9
6-benzoyl-5-(benzyloxy)-1,2-dihydro-8-methyl-3-(phenylsulfonyl)-1-vinyl-3H-pyrrolo<3,2-e>indole

Guidance literature:: Multi-step reaction with 9 steps

1: 94 percent / K₂CO₃ / n-Bu₄NI / acetone / 16 h / Heating

2: 90 percent / Na₂S₂O₄ / tetrahydrofuran; H₂O / 30 h / Heating

3: pyridine / tetrahydrofuran / 18 h / 22 °C

4: 84 percent / lead tetraacetate / benzene / 8 h / 22 °C

5: CH₂Cl₂ / 10 h / 23 °C

6: 10percent aq. hydrochloric acid / tetrahydrofuran / 20 h / 23 °C

7: 99 percent / conc. sulfuric acid, N-bromosuccinimide / tetrahydrofuran / 1 h / -23 °C

8: 1.) sodium hydride / dimethylformamide / 1.) 24 deg C, 10 min; 2.) 24 deg C, 16 h

9: 95 percent / tri-n-butyltin hydride / AIBN / benzene / 2.5 h / Heating

With pyridine; lead(IV) acetate; hydrogenchloride; N-Bromosuccinimide; sodium dithionite; sulfuric acid; tri-n-butyl-tin hydride; sodium hydride; potassium carbonate; 2,2'-azobis(isobutyronitrile); tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1021/ja00222a043

Reference yield:

: 112764-63-3
N⁵-(Phenylsulfonyl)-5-amino-1-benzoyl-7-(benzyloxy)-3-methylindole

: 114996-69-9
6-benzoyl-5-(benzyloxy)-1,2-dihydro-8-methyl-3-(phenylsulfonyl)-1-vinyl-3H-pyrrolo<3,2-e>indole

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / conc. sulfuric acid, N-bromosuccinimide / tetrahydrofuran / 1 h / -23 °C

2: 1.) sodium hydride / dimethylformamide / 1.) 24 deg C, 10 min; 2.) 24 deg C, 16 h

3: 95 percent / tri-n-butyltin hydride / AIBN / benzene / 2.5 h / Heating

With N-Bromosuccinimide; sulfuric acid; tri-n-butyl-tin hydride; sodium hydride; 2,2'-azobis(isobutyronitrile); In tetrahydrofuran; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ja00222a043