L-2,5-Dimethoxyphenylalanine

Base Information

• Chemical Name: L-2,5-Dimethoxyphenylalanine
• CAS No.: 730927-12-5
• Molecular Formula: C₁₁H₁₅NO₄
• Molecular Weight: 225.244
• Mol file: 730927-12-5.mol

Synonyms:L-2,5-Dimethoxyphenylalanine

Chemical Property of L-2,5-Dimethoxyphenylalanine

Chemical Property:

• Boiling Point: 383.3±42.0 °C(Predicted)
• PKA: 2.27±0.15(Predicted)
• PSA: 81.78000
• Density: 1.214±0.06 g/cm3(Predicted)
• LogP: 1.35850

Purity/Quality:

99% ^*data from raw suppliers

L-2,5-DIMETHOXYPHENYLALANINE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-2,5-Dimethoxyphenylalanine

There total 4 articles about L-2,5-Dimethoxyphenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(2,5-dimethoxybenzyl)imidazolidine-2,4-dione (76605-47-5) → 2-amino-3-(2,5-dimethoxyphenyl)propanoic acid (114872-64-9,91280-31-8,730927-12-5)

Guidance literature:

5-(2,5-dimethoxybenzyl)imidazolidine-2,4-dione; With barium hydroxide octahydrate; In water; for 48h; Reflux;

With sulfuric acid; In water; pH=6.5;

With ammonium hydroxide; In water; pH=9;

DOI:10.1016/j.tet.2012.01.005

Reference yield:

N-acetyl-(2,5-dimethoxyphenyl)alanine (51954-64-4) → L-(2,5-dimethoxyphenyl)alanine (730927-12-5)

Guidance literature:

With sodium hydroxide; at 37 ℃; for 72h; acylase from Aspergillus genus;

DOI:10.1246/cl.1993.1499

Reference yield:

2,5-dimethoxybenzaldehyde (93-02-7) → 2-amino-3-(2,5-dimethoxyphenyl)propanoic acid (114872-64-9,91280-31-8,730927-12-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium acetate; acetic anhydride; acetic acid / 3 h / 170 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / ethanol / 5 h / 20 °C / 2585.81 Torr

3.1: barium hydroxide octahydrate / water / 48 h / Reflux

3.2: pH 6.5

3.3: pH 9

With barium hydroxide octahydrate; palladium 10% on activated carbon; hydrogen; sodium acetate; acetic anhydride; acetic acid; In ethanol; water;

DOI:10.1016/j.tet.2012.01.005

upstream raw materials:

5-(2,5-dimethoxybenzyl)imidazolidine-2,4-dione

2,5-dimethoxybenzaldehyde

N-acetyl-(2,5-dimethoxyphenyl)alanine