S-(pyridin-2-yl) 4-methylbenzenesulfonothioate

Base Information

• Chemical Name: S-(pyridin-2-yl) 4-methylbenzenesulfonothioate
• CAS No.: 127878-51-7
• Molecular Formula: C₁₂H₁₁NO₂S₂
• Molecular Weight: 265.357
• Mol file: 127878-51-7.mol

Synonyms:S-(pyridin-2-yl) 4-methylbenzenesulfonothioate

Chemical Property of S-(pyridin-2-yl) 4-methylbenzenesulfonothioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of S-(pyridin-2-yl) 4-methylbenzenesulfonothioate

There total 16 articles about S-(pyridin-2-yl) 4-methylbenzenesulfonothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-Sulfanylpyridine (2637-34-5,73018-10-7) + p-toluenesulfonyl chloride (98-59-9) → S-(pyridin-2-yl) 4-methylbenzenesulfonothioate (127878-51-7)

Guidance literature:

With triethylamine; In dichloromethane; a) 0 deg C, 2 h, b) r.t., 2 h;

DOI:10.1016/S0040-4020(01)88524-0

Reference yield: 80.0%

Dithiocarbonic acid O-[1-hexyl-2-(toluene-4-sulfonyl)-nonyl] ester S-methyl ester (144432-93-9,144432-97-3) → S,S-dimethyl dithiocarbonate (868-84-8) + (E)-pentadec-7-ene (16416-37-8) + S-(pyridin-2-yl) 4-methylbenzenesulfonothioate (127878-51-7) + (Z)-pentadec-7-ene (74392-28-2)

Guidance literature:

With O-Acetyl N-hydroxy-2-thiopyridone; In dichloromethane; at 40 ℃; Yield given. Further byproducts given. Title compound not separated from byproducts; Irradiation;

DOI:10.1016/S0040-4020(01)88251-X

Reference yield: 80.0%

O-Acetyl N-hydroxy-2-thiopyridone (15922-79-9) + Dithiocarbonic acid O-[1-hexyl-2-(toluene-4-sulfonyl)-nonyl] ester S-methyl ester (144432-93-9,144432-97-3) → S,S-dimethyl dithiocarbonate (868-84-8) + (E)-pentadec-7-ene (16416-37-8) + S-(pyridin-2-yl) 4-methylbenzenesulfonothioate (127878-51-7) + (Z)-pentadec-7-ene (74392-28-2)

Guidance literature:

In dichloromethane; at 40 ℃; Further byproducts given. Yields of byproduct given; Irradiation;

DOI:10.1016/S0040-4020(01)88251-X

upstream raw materials:

2-Sulfanylpyridine

p-toluenesulfonyl chloride

O-Acetyl N-hydroxy-2-thiopyridone

seleno-(2-pyridyl) p-tolueneselenosulfonate

Downstream raw materials:

2-thiocyanatopyridine

potassium 4-methylbenzenesulfinate

Refernces

• 1、 Dong, Yue,Ji, Peng,Zhang, Yueteng,Wang, Changqing,Meng, Xiang,Wang, Wei. "Organophotoredox-Catalyzed Formation of Alkyl-Aryl and -Alkyl C-S/Se Bonds from Coupling of Redox-Active Esters with Thio/Selenosulfonates". supporting information. p. 9562 - 9567. Retrieved 2021/01/09.
• 2、 Zhang, Guo-Yu,Lv, Shuai-Shuai,Shoberu, Adedamola,Zou, Jian-Ping. "Copper-Catalyzed TBHP-Mediated Radical Cross-Coupling Reaction of Sulfonylhydrazides with Thiols Leading to Thiosulfonates". . p. 9801 - 9807. Retrieved 2017/09/22.