1-Tert-butyl 2-methyl 4,4-difluoropyrrolidine-1,2-dicarboxylate

Base Information

Chemical Name:1-Tert-butyl 2-methyl 4,4-difluoropyrrolidine-1,2-dicarboxylate
CAS No.:1000313-00-7
Molecular Formula:C₁₁H₁₇F₂NO₄
Molecular Weight:265.257
Hs Code.:
European Community (EC) Number:846-264-8

Synonyms:1-tert-butyl 2-methyl 4,4-difluoropyrrolidine-1,2-dicarboxylate;1000313-00-7;MFCD03094918;N-Boc-4,4-difluoro-DL-proline Methyl Ester;SCHEMBL1701540;MFCD09263325;AKOS023091058;AT19459;PB27589;SB20855;SY017434;SY286043;FT-0772213;BOC-4,4-DIFLUORO-L-PROLINEMETHYLESTER;EN300-135584;Z1505717013;1-tert-butyl2-methyl4,4-difluoropyrrolidine-1,2-dicarboxylate;methyl 1-(tert-butoxycarbonyl)-4,4-difluoropyrrolidine-2-carboxylate;1-(TERT-BUTYL) 2-METHYL 4,4-DIFLUOROPYRROLIDINE-1,2-DICARBOXYLATE;1-O-tert-butyl 2-O-methyl 4,4-difluoropyrrolidine-1,2-dicarboxylate;4,4-Difluoro-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester;(S)-1-tert-butyl 2-methyl 4,4-difluoropyrrolidine-1,2-dicarboxylate;N-BOC-4,4-DIFLUORO-L-PROLINE METHYL ESTER;1-tert-butyl 2-methyl (2S)-4,4-difluoropyrrolidine-1,2-dicarboxylate

Suppliers and Price of 1-Tert-butyl 2-methyl 4,4-difluoropyrrolidine-1,2-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 2 raw suppliers

Chemical Property of 1-Tert-butyl 2-methyl 4,4-difluoropyrrolidine-1,2-dicarboxylate

Chemical Property:

XLogP3:1.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:265.11256435
Heavy Atom Count:18
Complexity:351

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CC(CC1C(=O)OC)(F)F

Technology Process of 1-Tert-butyl 2-methyl 4,4-difluoropyrrolidine-1,2-dicarboxylate

There total 1 articles about 1-Tert-butyl 2-methyl 4,4-difluoropyrrolidine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 876317-19-0
⁽²⁸⁾-1-(tert-butoxycarbonyl)-4-oxo-2-pyrrolidinecarboxylic acid

: 1000313-00-7
1-(tert-butyl) 2-methyl 4,4-difluoropyrrolidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 2 h / Reflux

2: diethylamino-sulfur trifluoride / dichloromethane / 20 °C / Inert atmosphere

With diethylamino-sulfur trifluoride; potassium carbonate; In dichloromethane; acetone;

Reference yield: 95.6%

: 1000313-00-7
1-(tert-butyl) 2-methyl 4,4-difluoropyrrolidine-1,2-dicarboxylate

: 1000313-01-8
1-(tert-butoxycarbonyl)-4,4-difluoropyrrolidine-2-carboxylic acid

Guidance literature:: 1-(tert-butyl) 2-methyl 4,4-difluoropyrrolidine-1,2-dicarboxylate; With lithium hydroxide; water; In acetonitrile; at 25 ℃; for 16h;

With hydrogenchloride; In water; acetonitrile;

Reference yield:

: 1000313-00-7
1-(tert-butyl) 2-methyl 4,4-difluoropyrrolidine-1,2-dicarboxylate

: C₁₉H₂₀FIN₄O₅S

Guidance literature:: Multi-step reaction with 9 steps

1: lithium hydroxide; water / acetonitrile / 16 h / 25 °C

2: sodium carbonate / Aliquat 336 / dichloromethane; water / 48 h / 25 °C

3: trifluoroacetic acid / dichloromethane / 16 h / 25 °C

4: manganese(IV) oxide / tetrahydrofuran / 4 h / 80 °C

5: sodium hydroxide; sodium hypochlorite; ammonia; ammonium chloride / Aliquat 336 / tert-butyl methyl ether; water / 2 h / 25 °C

6: sodium cyanoborohydride / methanol / 20 h / 25 °C

7: 1,4-dioxane / 1 h / 100 °C

8: sodium ethanolate / ethanol / 16 h / 40 °C

9: pyridine / 3 h / 120 °C

With manganese(IV) oxide; lithium hydroxide; sodium hydroxide; sodium hypochlorite; ammonia; water; sodium ethanolate; sodium cyanoborohydride; sodium carbonate; ammonium chloride; trifluoroacetic acid; Aliquat 336; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; ethanol; dichloromethane; tert-butyl methyl ether; water; acetonitrile;