Technology Process of trans-(1S,2R)-2-(3,4-difluorophenyl)-1-nitrocyclopropane
There total 6 articles about trans-(1S,2R)-2-(3,4-difluorophenyl)-1-nitrocyclopropane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
methanesulfonyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 13h;
- Guidance literature:
-
With
triphenylphosphine; diethylazodicarboxylate;
In
toluene;
at 0 - 10 ℃;
for 2h;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: aluminum (III) chloride / dichloromethane / 4 h / 20 - 25 °C / Industry scale
2: sodium iodide; 3,5-dihydroxyphenol; sodium nitrite / N,N-dimethyl-formamide / 5 - 30 °C / Inert atmosphere
3: dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene; tetrahydrofuran / 4 h / 25 - 30 °C / Inert atmosphere
4: triphenylphosphine; diethylazodicarboxylate / toluene / 2 h / 0 - 10 °C
With
aluminum (III) chloride; 3,5-dihydroxyphenol; dimethylsulfide borane complex; triphenylphosphine; sodium iodide; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; sodium nitrite; diethylazodicarboxylate;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
