(1S,2R,4R)-4-Benzyloxy-2-diphenylphosphinoyl-1-(2-furyl)octan-1-ol

Base Information

• Chemical Name: (1S,2R,4R)-4-Benzyloxy-2-diphenylphosphinoyl-1-(2-furyl)octan-1-ol
• CAS No.: 204506-05-8
• Molecular Formula: C₃₁H₃₅O₄P
• Molecular Weight: 502.59
• Mol file: 204506-05-8.mol

Synonyms:(1S,2R,4R)-4-Benzyloxy-2-diphenylphosphinoyl-1-(2-furyl)octan-1-ol

Chemical Property of (1S,2R,4R)-4-Benzyloxy-2-diphenylphosphinoyl-1-(2-furyl)octan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2R,4R)-4-Benzyloxy-2-diphenylphosphinoyl-1-(2-furyl)octan-1-ol

There total 2 articles about (1S,2R,4R)-4-Benzyloxy-2-diphenylphosphinoyl-1-(2-furyl)octan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

furfural (98-01-1) + 1-Diphenylphosphinoylheptan-3-yl benzyl ether → (1S,2R,4R)-4-Benzyloxy-2-diphenylphosphinoyl-1-(2-furyl)octan-1-ol (204506-05-8) + (1R,2S,4R)-4-Benzyloxy-2-diphenylphosphinoyl-1-(2-furyl)octan-1-ol

Guidance literature:

1-Diphenylphosphinoylheptan-3-yl benzyl ether; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h;

furfural; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1.5h;

DOI:10.1039/a903370j

Reference yield:

furfural (98-01-1) + (R)-1-Diphenylphosphinoylheptan-3-yl benzyl ether (183311-78-6) → (1S,2R,4R)-4-Benzyloxy-2-diphenylphosphinoyl-1-(2-furyl)octan-1-ol (204506-05-8) + (1R,2S,4R)-4-Benzyloxy-2-diphenylphosphinoyl-1-(2-furyl)octan-1-ol

Guidance literature:

With n-butyllithium; In tetrahydrofuran; Yield given. Yields of byproduct given;

DOI:10.1016/S0040-4039(97)10859-0

Reference yield: 95.0%

(1S,2R,4R)-4-Benzyloxy-2-diphenylphosphinoyl-1-(2-furyl)octan-1-ol (204506-05-8) → (2S, 1'R, 3'R)-2-(3'-Benzyloxy-1'-diphenylphosphinoylheptyl)-6-hydroxy-3,6-dihydro-2H-pyran-3-one (245356-64-3)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1016/S0040-4039(97)10859-0

upstream raw materials:

furfural

(R)-1-Diphenylphosphinoylheptan-3-yl benzyl ether

Downstream raw materials:

(1R,2R,4R)-4-Benzyloxy-2-diphenylphosphinoyl-1-(2-furyl)octan-1-ol

(2S, 1'R, 3'R)-2-(3'-Benzyloxy-1'-diphenylphosphinoylheptyl)-6-hydroxy-3,6-dihydro-2H-pyran-3-one

(4S,5R,6R,8R)-8-Benzyloxy-6-(diphenyl-phosphinoyl)-dodecane-1,4,5-triol

(4R,5S,6R,8R)-8-Benzyloxy-6-diphenylphosphinoyldodecane-1,4,5-triol