tert-butyl 3-((5-(5,7-difluoro-4-oxo-3,4-dihydroquinazolin-2-yl)-4'-(methylsulfinyl)-[1,1'-biphenyl]-2-yl)oxy)azetidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 3-((5-(5,7-difluoro-4-oxo-3,4-dihydroquinazolin-2-yl)-4'-(methylsulfinyl)-[1,1'-biphenyl]-2-yl)oxy)azetidine-1-carboxylate
CAS No.:1610373-05-1
Molecular Formula:C₂₉H₂₇F₂N₃O₅S
Molecular Weight:567.613
Hs Code.:

Synonyms:tert-butyl 3-((5-(5,7-difluoro-4-oxo-3,4-dihydroquinazolin-2-yl)-4'-(methylsulfinyl)-[1,1'-biphenyl]-2-yl)oxy)azetidine-1-carboxylate

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Chemical Property of tert-butyl 3-((5-(5,7-difluoro-4-oxo-3,4-dihydroquinazolin-2-yl)-4'-(methylsulfinyl)-[1,1'-biphenyl]-2-yl)oxy)azetidine-1-carboxylate

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Technology Process of tert-butyl 3-((5-(5,7-difluoro-4-oxo-3,4-dihydroquinazolin-2-yl)-4'-(methylsulfinyl)-[1,1'-biphenyl]-2-yl)oxy)azetidine-1-carboxylate

There total 5 articles about tert-butyl 3-((5-(5,7-difluoro-4-oxo-3,4-dihydroquinazolin-2-yl)-4'-(methylsulfinyl)-[1,1'-biphenyl]-2-yl)oxy)azetidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 893428-66-5
2-amino-4,6-difluoro-benzamide

: 1610373-04-0
tert-butyl 3-(5-formyl-4'-(methylsulfinyl)biphenyl-2-yloxy)azetidine-1-carboxylate

: 1610373-05-1
tert-butyl 3-((5-(5,7-difluoro-4-oxo-3,4-dihydroquinazolin-2-yl)-4'-(methylsulfinyl)-[1,1'-biphenyl]-2-yl)oxy)azetidine-1-carboxylate

Guidance literature:: With toluene-4-sulfonic acid; sodium hydrogensulfite; In dimethyl amine; at 110 ℃; for 16h;

Reference yield:

: 166386-48-7
(4-(methylsulfinyl)phenyl)boronic acid

: 1610373-05-1
tert-butyl 3-((5-(5,7-difluoro-4-oxo-3,4-dihydroquinazolin-2-yl)-4'-(methylsulfinyl)-[1,1'-biphenyl]-2-yl)oxy)azetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

2: toluene-4-sulfonic acid; sodium hydrogensulfite / dimethyl amine / 16 h / 110 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; toluene-4-sulfonic acid; sodium hydrogensulfite; In 1,4-dioxane; water; dimethyl amine;

Reference yield:

: 141699-58-3
3-methanesulfonyloxy-azetidine-1-carboxylic acid tert-butyl ester

: 1610373-05-1
tert-butyl 3-((5-(5,7-difluoro-4-oxo-3,4-dihydroquinazolin-2-yl)-4'-(methylsulfinyl)-[1,1'-biphenyl]-2-yl)oxy)azetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 21915 h / 80 °C

1.2: 18 h / 80 °C

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

3.1: toluene-4-sulfonic acid; sodium hydrogensulfite / dimethyl amine / 16 h / 110 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; toluene-4-sulfonic acid; sodium hydrogensulfite; In 1,4-dioxane; water; dimethyl amine; N,N-dimethyl-formamide;