1-<3-chloro-2,3-dideoxy-5-O-(triphenylmethyl)-β-D-threo-pentofuranosyl>-2,4(1H,3H)-pyrimidinedione

Base Information

• Chemical Name: 1-<3-chloro-2,3-dideoxy-5-O-(triphenylmethyl)-β-D-threo-pentofuranosyl>-2,4(1H,3H)-pyrimidinedione
• CAS No.: 85236-88-0
• Molecular Formula: C₂₈H₂₅ClN₂O₄
• Molecular Weight: 488.971

Synonyms:1-<3-chloro-2,3-dideoxy-5-O-(triphenylmethyl)-β-D-threo-pentofuranosyl>-2,4(1H,3H)-pyrimidinedione

Chemical Property of 1-<3-chloro-2,3-dideoxy-5-O-(triphenylmethyl)-β-D-threo-pentofuranosyl>-2,4(1H,3H)-pyrimidinedione

Chemical Property:

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Technology Process of 1-<3-chloro-2,3-dideoxy-5-O-(triphenylmethyl)-β-D-threo-pentofuranosyl>-2,4(1H,3H)-pyrimidinedione

There total 3 articles about 1-<3-chloro-2,3-dideoxy-5-O-(triphenylmethyl)-β-D-threo-pentofuranosyl>-2,4(1H,3H)-pyrimidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

O5'-trityl-2'-deoxy-uridine (14270-73-6) → 1-<3-chloro-2,3-dideoxy-5-O-(triphenylmethyl)-β-D-threo-pentofuranosyl>-2,4(1H,3H)-pyrimidinedione (85236-88-0)

Guidance literature:

With tetrachloromethane; triphenylphosphine; In N,N-dimethyl acetamide; at 24 ℃; for 18h;

DOI:10.1021/jm00360a019

Reference yield:

2'-deoxyuridine (951-78-0,63844-76-8) → 1-<3-chloro-2,3-dideoxy-5-O-(triphenylmethyl)-β-D-threo-pentofuranosyl>-2,4(1H,3H)-pyrimidinedione (85236-88-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 12.58 g / pyridine / 18 h / 100 °C

2: triphenylphosphine, CCl₄ / N,N-dimethyl-acetamide / 18 h / 24 °C

With pyridine; tetrachloromethane; triphenylphosphine; In N,N-dimethyl acetamide;

DOI:10.1021/jm00360a019

Reference yield:

trityl chloride (76-83-5) → 1-<3-chloro-2,3-dideoxy-5-O-(triphenylmethyl)-β-D-threo-pentofuranosyl>-2,4(1H,3H)-pyrimidinedione (85236-88-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 12.58 g / pyridine / 18 h / 100 °C

2: triphenylphosphine, CCl₄ / N,N-dimethyl-acetamide / 18 h / 24 °C

With pyridine; tetrachloromethane; triphenylphosphine; In N,N-dimethyl acetamide;

DOI:10.1021/jm00360a019

upstream raw materials:

O^5'-trityl-2'-deoxy-uridine

2'-deoxyuridine

trityl chloride

Downstream raw materials:

3'-amino-2',3'-dideoxyuridine

3'-azido-2',3'-dideoxycytidine

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