(5S,6R,7R,12S,3'S,3S)-5,12-Bis(3-phenylbutanoyloxy)-1,8,13,16-tetraoxadispiro<5.0.5.4>hexadecane

Base Information

Chemical Name:(5S,6R,7R,12S,3'S,3S)-5,12-Bis(3-phenylbutanoyloxy)-1,8,13,16-tetraoxadispiro<5.0.5.4>hexadecane
CAS No.:169870-75-1
Molecular Formula:C₃₂H₄₀O₈
Molecular Weight:552.665
Hs Code.:

Synonyms:(5S,6R,7R,12S,3'S,3S)-5,12-Bis(3-phenylbutanoyloxy)-1,8,13,16-tetraoxadispiro<5.0.5.4>hexadecane

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Chemical Property of (5S,6R,7R,12S,3'S,3S)-5,12-Bis(3-phenylbutanoyloxy)-1,8,13,16-tetraoxadispiro<5.0.5.4>hexadecane

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Technology Process of (5S,6R,7R,12S,3'S,3S)-5,12-Bis(3-phenylbutanoyloxy)-1,8,13,16-tetraoxadispiro<5.0.5.4>hexadecane

There total 3 articles about (5S,6R,7R,12S,3'S,3S)-5,12-Bis(3-phenylbutanoyloxy)-1,8,13,16-tetraoxadispiro<5.0.5.4>hexadecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 917-54-4
methyllithium

: 169870-72-8
(5S,6R,7R,12S,2'E,2E)-5,12-Bis(3-phenylprop-2-enoyloxy)-1,8,13,16-tetraoxadispiro<5.0.5.4>hexadecane

: 169870-75-1
(5S,6R,7R,12S,3'S,3S)-5,12-Bis(3-phenylbutanoyloxy)-1,8,13,16-tetraoxadispiro<5.0.5.4>hexadecane

: 169870-71-7
(5S,6R,7R,12S,3'R,3R)-5,12-Bis(3-phenylbutanoyloxy)-1,8,13,16-tetraoxadispiro<5.0.5.4>hexadecane

Guidance literature:: With CuI*P(n-Bu)3; boron trifluoride diethyl etherate; In diethyl ether; at -60 ℃; for 16h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1016/0040-4039(94)85340-1

Reference yield:

: 591-51-5
phenyllithium

: 169870-70-6
(5S,6R,7R,12S,2'E,2E)-5,12-Bis(but-2-enoyloxy)-1,8,13,16-tetraoxadispiro<5.0.5.4>hexadecane

: 169870-75-1
(5S,6R,7R,12S,3'S,3S)-5,12-Bis(3-phenylbutanoyloxy)-1,8,13,16-tetraoxadispiro<5.0.5.4>hexadecane

: 169870-71-7
(5S,6R,7R,12S,3'R,3R)-5,12-Bis(3-phenylbutanoyloxy)-1,8,13,16-tetraoxadispiro<5.0.5.4>hexadecane

Guidance literature:: With CuI*P(n-Bu)3; boron trifluoride diethyl etherate; In diethyl ether; at -40 ℃; for 36h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1016/0040-4039(94)85340-1

Reference yield:

: 160400-00-0
(5S,6R,7R,12S)-1,8,13,16-Tetraoxa-dispiro[5.0.5.4]hexadecane-5,12-diol

: 169870-75-1
(5S,6R,7R,12S,3'S,3S)-5,12-Bis(3-phenylbutanoyloxy)-1,8,13,16-tetraoxadispiro<5.0.5.4>hexadecane

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / t-BuOK / tetrahydrofuran / 0 deg C to rt; -78 deg C

2: CuI*PBu₃, BF₃*OEt₂ / diethyl ether / 36 h / -40 °C

With CuI*P(n-Bu)3; boron trifluoride diethyl etherate; potassium tert-butylate; In tetrahydrofuran; diethyl ether;
DOI:10.1016/0040-4039(94)85340-1