thioacetic acid S-[(S)-6-[((R)-5-oxo-pyrrolidine-2-carbonyl)-amino]-6-(3-trifluoromethyl-phenylcarbamoyl)-hexyl] ester

Base Information

• Chemical Name: thioacetic acid S-[(S)-6-[((R)-5-oxo-pyrrolidine-2-carbonyl)-amino]-6-(3-trifluoromethyl-phenylcarbamoyl)-hexyl] ester
• CAS No.: 1428535-89-0
• Molecular Formula: C₂₁H₂₆F₃N₃O₄S
• Molecular Weight: 473.516
• Mol file: 1428535-89-0.mol

Synonyms:thioacetic acid S-[(S)-6-[((R)-5-oxo-pyrrolidine-2-carbonyl)-amino]-6-(3-trifluoromethyl-phenylcarbamoyl)-hexyl] ester

Chemical Property of thioacetic acid S-[(S)-6-[((R)-5-oxo-pyrrolidine-2-carbonyl)-amino]-6-(3-trifluoromethyl-phenylcarbamoyl)-hexyl] ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of thioacetic acid S-[(S)-6-[((R)-5-oxo-pyrrolidine-2-carbonyl)-amino]-6-(3-trifluoromethyl-phenylcarbamoyl)-hexyl] ester

There total 6 articles about thioacetic acid S-[(S)-6-[((R)-5-oxo-pyrrolidine-2-carbonyl)-amino]-6-(3-trifluoromethyl-phenylcarbamoyl)-hexyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

C16H21F3N2O2S*C2HF3O2 + D-pyrrolidone-5-carboxylic acid (4042-36-8) → thioacetic acid S-[(S)-6-[((R)-5-oxo-pyrrolidine-2-carbonyl)-amino]-6-(3-trifluoromethyl-phenylcarbamoyl)-hexyl] ester (1428535-89-0)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmcl.2014.12.051

Reference yield: 84.0%

→ thioacetic acid S-[(S)-6-[((R)-5-oxo-pyrrolidine-2-carbonyl)-amino]-6-(3-trifluoromethyl-phenylcarbamoyl)-hexyl] ester (1428535-89-0)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); In 1,4-dioxane; at 75 ℃;

Reference yield:

3-trifluoromethylaniline (98-16-8) → thioacetic acid S-[(S)-6-[((R)-5-oxo-pyrrolidine-2-carbonyl)-amino]-6-(3-trifluoromethyl-phenylcarbamoyl)-hexyl] ester (1428535-89-0)

Guidance literature:

Multi-step reaction with 4 steps

1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide; dichloromethane / 20 °C

2: 2,2'-azobis(isobutyronitrile) / 1,4-dioxane / 75 °C

3: dichloromethane / 0 - 20 °C

4: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide; dichloromethane / 20 °C

With 2,2'-azobis(isobutyronitrile); benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2014.12.051

upstream raw materials:

3-trifluoromethylaniline

tert-butyl N-[(1S)-1-[[3-(trifluoromethyl)phenyl]carbamoyl]hex-5-enyl]carbamate

D-pyrrolidone-5-carboxylic acid

(2S)-2-[(tert-butoxycarbonyl)amino]hept-6-enoic acid