ethyl N-{[2-(2'-ethoxybiphenyl-4-yl)-6-fluoro-3-methylquinolin-4-yl]carbonyl}glycinate

Base Information

Chemical Name:ethyl N-{[2-(2'-ethoxybiphenyl-4-yl)-6-fluoro-3-methylquinolin-4-yl]carbonyl}glycinate
CAS No.:881314-18-7
Molecular Formula:C₂₉H₂₇FN₂O₄
Molecular Weight:486.543
Hs Code.:

Synonyms:ethyl N-{[2-(2'-ethoxybiphenyl-4-yl)-6-fluoro-3-methylquinolin-4-yl]carbonyl}glycinate

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Chemical Property of ethyl N-{[2-(2'-ethoxybiphenyl-4-yl)-6-fluoro-3-methylquinolin-4-yl]carbonyl}glycinate

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Technology Process of ethyl N-{[2-(2'-ethoxybiphenyl-4-yl)-6-fluoro-3-methylquinolin-4-yl]carbonyl}glycinate

There total 1 articles about ethyl N-{[2-(2'-ethoxybiphenyl-4-yl)-6-fluoro-3-methylquinolin-4-yl]carbonyl}glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 641611-84-9
2-(2'-ethoxybiphenyl-4-yl)-6-fluoro-3-methylquinoline-4-carboxylic acid

: 623-33-6
glycine ethyl ester hydrochloride

: 881314-18-7
ethyl N-{[2-(2'-ethoxybiphenyl-4-yl)-6-fluoro-3-methylquinolin-4-yl]carbonyl}glycinate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 52.0%

: 881314-18-7
ethyl N-{[2-(2'-ethoxybiphenyl-4-yl)-6-fluoro-3-methylquinolin-4-yl]carbonyl}glycinate

: 881314-19-8
N-{[2-(2'-ethoxybiphenyl-4-yl)-6-fluoro-3-methylquinolin-4-yl]carbonyl}glycine

Guidance literature:: ethyl N-{[2-(2'-ethoxybiphenyl-4-yl)-6-fluoro-3-methylquinolin-4-yl]carbonyl}glycinate; With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 1h;

With acetic acid; In water; pH=7;