(2R,3S)-ethyl 3-(1H-indol-3-yl)-2-(4-methylphenylsulfonamido)butanoate

Base Information

Chemical Name:(2R,3S)-ethyl 3-(1H-indol-3-yl)-2-(4-methylphenylsulfonamido)butanoate
CAS No.:1610027-03-6
Molecular Formula:C₂₁H₂₄N₂O₄S
Molecular Weight:400.499
Hs Code.:

Synonyms:(2R,3S)-ethyl 3-(1H-indol-3-yl)-2-(4-methylphenylsulfonamido)butanoate

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Chemical Property of (2R,3S)-ethyl 3-(1H-indol-3-yl)-2-(4-methylphenylsulfonamido)butanoate

Chemical Property:

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Technology Process of (2R,3S)-ethyl 3-(1H-indol-3-yl)-2-(4-methylphenylsulfonamido)butanoate

There total 1 articles about (2R,3S)-ethyl 3-(1H-indol-3-yl)-2-(4-methylphenylsulfonamido)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 697306-96-0
ethyl (2R,3S)-2-amino-3-(1H-indol-3-yl)butanoate methanesulfonate

: 98-59-9
p-toluenesulfonyl chloride

: 1610027-03-6
(2R,3S)-ethyl 3-(1H-indol-3-yl)-2-(4-methylphenylsulfonamido)butanoate

Guidance literature:: ethyl (2R,3S)-2-amino-3-(1H-indol-3-yl)butanoate methanesulfonate; With dmap; triethylamine; In dichloromethane; at 0 ℃; for 0.166667h; Inert atmosphere;

p-toluenesulfonyl chloride; With dmap; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/ol500990f

Reference yield: 94.0%

: 1610027-03-6
(2R,3S)-ethyl 3-(1H-indol-3-yl)-2-(4-methylphenylsulfonamido)butanoate

: 1048677-83-3
(2R,3S)-3-(1H-indol-3-yl)-2-(4-methylphenylsulfonamido)butanoic acid

Guidance literature:: (2R,3S)-ethyl 3-(1H-indol-3-yl)-2-(4-methylphenylsulfonamido)butanoate; With lithium hydroxide monohydrate; In tetrahydrofuran; ethanol; for 14h; Reflux; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; ethanol;
DOI:10.1021/ol500990f

Reference yield:

: 1610027-03-6
(2R,3S)-ethyl 3-(1H-indol-3-yl)-2-(4-methylphenylsulfonamido)butanoate

: 1610027-04-7
C₂₃H₂₇BN₂O₄S

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate / tetrahydrofuran; ethanol / 14 h / Reflux; Inert atmosphere

2: dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

With lithium hydroxide monohydrate; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ol500990f