N-allyl-N-((2R,3R)-3-hydroxy-1-phenylpent-4-yn-2-yl)-2-nitrobenzenesulfonamide

Base Information

• Chemical Name: N-allyl-N-((2R,3R)-3-hydroxy-1-phenylpent-4-yn-2-yl)-2-nitrobenzenesulfonamide
• CAS No.: 1226968-00-8
• Molecular Formula: C₂₀H₂₀N₂O₅S
• Molecular Weight: 400.455

Synonyms:N-allyl-N-((2R,3R)-3-hydroxy-1-phenylpent-4-yn-2-yl)-2-nitrobenzenesulfonamide

Chemical Property of N-allyl-N-((2R,3R)-3-hydroxy-1-phenylpent-4-yn-2-yl)-2-nitrobenzenesulfonamide

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Technology Process of N-allyl-N-((2R,3R)-3-hydroxy-1-phenylpent-4-yn-2-yl)-2-nitrobenzenesulfonamide

There total 1 articles about N-allyl-N-((2R,3R)-3-hydroxy-1-phenylpent-4-yn-2-yl)-2-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-allyl-N-((2R,3R)-3-hydroxy-1-phenyl-5-(triethylsilyl)pent-4-yn-2-yl)-2-nitrobenzenesulfonamide (1226967-96-9) → N-allyl-N-((2R,3R)-3-hydroxy-1-phenylpent-4-yn-2-yl)-2-nitrobenzenesulfonamide (1226968-00-8)

Guidance literature:

With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; water; at 0 ℃; for 5h; Inert atmosphere;

DOI:10.1021/ol100914b

Reference yield: 90.0%

N-allyl-N-((2R,3R)-3-hydroxy-1-phenylpent-4-yn-2-yl)-2-nitrobenzenesulfonamide (1226968-00-8) + acetic anhydride (108-24-7) → (3R,4R)-4-(N-allyl-2-nitrophenylsulfonamido)-5-phenylpent-1-yn-3-yl acetate (1226968-04-2)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 ℃;

DOI:10.1021/ol100914b

Reference yield: 70.0%

N-allyl-N-((2R,3R)-3-hydroxy-1-phenylpent-4-yn-2-yl)-2-nitrobenzenesulfonamide (1226968-00-8) → (2R,3R)-N-allyl-3-(2-nitrophenoxy)-1-phenylpent-4-yn-2-amine (1226968-13-3)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 64 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ol100914b

upstream raw materials:

N-allyl-N-((2R,3R)-3-hydroxy-1-phenyl-5-(triethylsilyl)pent-4-yn-2-yl)-2-nitrobenzenesulfonamide

Downstream raw materials:

(2R,3R)-2-benzyl-1-(2-nitrophenylsulfonyl)-4-vinyl-1,2,3,6-tetrahydropyridin-3-ol

(2R,3R)-N-allyl-3-(2-nitrophenoxy)-1-phenylpent-4-yn-2-amine

(3R,4R)-3-benzyl-4-ethynyl-2-prop-2-en-1-yl-3,4-dihydro-2H-5,1,2-benzoxathiazepine 1,1-dioxide

(3R,4R)-4-(N-allyl-2-nitrophenylsulfonamido)-5-phenylpent-1-yn-3-yl acetate

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