acetic acid 6-(tert-butyl-dimethyl-silanyloxy)-3-(1-methyl-6-phenyl-hex-2-ynyloxy)-hex-2-enyl ester

Base Information

Chemical Name:acetic acid 6-(tert-butyl-dimethyl-silanyloxy)-3-(1-methyl-6-phenyl-hex-2-ynyloxy)-hex-2-enyl ester
CAS No.:902513-97-7
Molecular Formula:C₂₇H₄₂O₄Si
Molecular Weight:458.714
Hs Code.:

acetic acid 6-(<i>tert</i>-butyl-dimethyl-silanyloxy)-3-(1-methyl-6-phenyl-hex-2-ynyloxy)-hex-2-enyl ester

Synonyms:acetic acid 6-(tert-butyl-dimethyl-silanyloxy)-3-(1-methyl-6-phenyl-hex-2-ynyloxy)-hex-2-enyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of acetic acid 6-(tert-butyl-dimethyl-silanyloxy)-3-(1-methyl-6-phenyl-hex-2-ynyloxy)-hex-2-enyl ester

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Technology Process of acetic acid 6-(tert-butyl-dimethyl-silanyloxy)-3-(1-methyl-6-phenyl-hex-2-ynyloxy)-hex-2-enyl ester

There total 4 articles about acetic acid 6-(tert-butyl-dimethyl-silanyloxy)-3-(1-methyl-6-phenyl-hex-2-ynyloxy)-hex-2-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 902513-96-6
6-(tert-butyl-dimethyl-silanyloxy)-3-(1-methyl-6-phenyl-hex-2-ynyloxy)-hex-2-en-1-ol

: 108-24-7
acetic anhydride

: 902513-97-7
acetic acid 6-(tert-butyl-dimethyl-silanyloxy)-3-(1-methyl-6-phenyl-hex-2-ynyloxy)-hex-2-enyl ester

Guidance literature:: With dmap; TEA; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/ja061344d

Reference yield:

: 6-(tert-butyl-dimethyl-silanyloxy)-3-(1-methyl-6-phenyl-hex-2-ynyloxy)-hex-2-enoic acid ethyl ester

: 902513-97-7
acetic acid 6-(tert-butyl-dimethyl-silanyloxy)-3-(1-methyl-6-phenyl-hex-2-ynyloxy)-hex-2-enyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / DIBAL-H / diethyl ether / 1 h / -78 °C

2: 93 percent / TEA; DMAP / CH₂Cl₂ / 12 h / 20 °C

With dmap; TEA; diisobutylaluminium hydride; In diethyl ether; dichloromethane;
DOI:10.1021/ja061344d

Reference yield:

: 101849-55-2
ethyl 6-((tert-butyldimethylsilyl)oxy)hex-2-ynoate

: 902513-97-7
acetic acid 6-(tert-butyl-dimethyl-silanyloxy)-3-(1-methyl-6-phenyl-hex-2-ynyloxy)-hex-2-enyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / NaH / tetrahydrofuran / 16 h / 20 °C

2: 72 percent / DIBAL-H / diethyl ether / 1 h / -78 °C

3: 93 percent / TEA; DMAP / CH₂Cl₂ / 12 h / 20 °C

With dmap; TEA; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ja061344d