Benzyl <2-(trimethylsilyl)ethyl 4,5,7,8-tetrakis-O-(chloroacetyl)-3-deoxy-α-D-manno-2-octulopyranosid>onate

Base Information

Chemical Name:Benzyl <2-(trimethylsilyl)ethyl 4,5,7,8-tetrakis-O-(chloroacetyl)-3-deoxy-α-D-manno-2-octulopyranosid>onate
CAS No.:128678-09-1
Molecular Formula:C₂₈H₃₆Cl₄O₁₂Si
Molecular Weight:734.484
Hs Code.:

Synonyms:Benzyl <2-(trimethylsilyl)ethyl 4,5,7,8-tetrakis-O-(chloroacetyl)-3-deoxy-α-D-manno-2-octulopyranosid>onate

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Chemical Property of Benzyl <2-(trimethylsilyl)ethyl 4,5,7,8-tetrakis-O-(chloroacetyl)-3-deoxy-α-D-manno-2-octulopyranosid>onate

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Technology Process of Benzyl <2-(trimethylsilyl)ethyl 4,5,7,8-tetrakis-O-(chloroacetyl)-3-deoxy-α-D-manno-2-octulopyranosid>onate

There total 5 articles about Benzyl <2-(trimethylsilyl)ethyl 4,5,7,8-tetrakis-O-(chloroacetyl)-3-deoxy-α-D-manno-2-octulopyranosid>onate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 128678-09-1
Benzyl <2-(trimethylsilyl)ethyl 4,5,7,8-tetrakis-O-(chloroacetyl)-3-deoxy-α-D-manno-2-octulopyranosid>onate

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / Ag₂CO₃, AgClO₄, molecular sieves 4A / CH₂Cl₂ / Ambient temperature

2: CH₃ONa / methanol

3: 1.) aq.KOH, 2.) K₂CO₃ / 1.) 1,4-dioxane, 1 h, r.t.; 2.) DMF, 12 h, r.t

4: 2,6-dimethylpyridine, Et₃N / CH₂Cl₂ / Ambient temperature

With 2,6-dimethylpyridine; potassium hydroxide; 4 A molecular sieve; sodium methylate; silver perchlorate; potassium carbonate; triethylamine; silver carbonate; In methanol; dichloromethane;
DOI:10.1016/0008-6215(90)84106-5

Reference yield:

: 128678-07-9
Methyl <2-(trimethylsilyl)ethyl 3-deoxy-α-D-manno-2-octulopyranosid>onate

: 128678-09-1
Benzyl <2-(trimethylsilyl)ethyl 4,5,7,8-tetrakis-O-(chloroacetyl)-3-deoxy-α-D-manno-2-octulopyranosid>onate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) aq.KOH, 2.) K₂CO₃ / 1.) 1,4-dioxane, 1 h, r.t.; 2.) DMF, 12 h, r.t

2: 2,6-dimethylpyridine, Et₃N / CH₂Cl₂ / Ambient temperature

With 2,6-dimethylpyridine; potassium hydroxide; potassium carbonate; triethylamine; In dichloromethane;
DOI:10.1016/0008-6215(90)84106-5

Reference yield:

: 85382-87-2
methyl (4,5,7,8-tetra-O-acetyl-3-deoxy-α-D-manno-oct-2-ulopyranosyl bromide)onate

: 128678-09-1
Benzyl <2-(trimethylsilyl)ethyl 4,5,7,8-tetrakis-O-(chloroacetyl)-3-deoxy-α-D-manno-2-octulopyranosid>onate

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / Ag₂CO₃, AgClO₄, molecular sieves 4A / CH₂Cl₂ / Ambient temperature

2: CH₃ONa / methanol

3: 1.) aq.KOH, 2.) K₂CO₃ / 1.) 1,4-dioxane, 1 h, r.t.; 2.) DMF, 12 h, r.t

4: 2,6-dimethylpyridine, Et₃N / CH₂Cl₂ / Ambient temperature

With 2,6-dimethylpyridine; potassium hydroxide; 4 A molecular sieve; sodium methylate; silver perchlorate; potassium carbonate; triethylamine; silver carbonate; In methanol; dichloromethane;
DOI:10.1016/0008-6215(90)84106-5