3,9-dimethyl-3,9-di(m-hydroxyphenyl)-2,4,8,10-tetraoxaspiro[5.5]undecane

Base Information

• Chemical Name: 3,9-dimethyl-3,9-di(m-hydroxyphenyl)-2,4,8,10-tetraoxaspiro[5.5]undecane
• CAS No.: 726173-39-3
• Molecular Formula: C₂₁H₂₄O₆
• Molecular Weight: 372.418
• Mol file: 726173-39-3.mol

Synonyms:3,9-dimethyl-3,9-di(m-hydroxyphenyl)-2,4,8,10-tetraoxaspiro[5.5]undecane

Chemical Property of 3,9-dimethyl-3,9-di(m-hydroxyphenyl)-2,4,8,10-tetraoxaspiro[5.5]undecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,9-dimethyl-3,9-di(m-hydroxyphenyl)-2,4,8,10-tetraoxaspiro[5.5]undecane

There total 2 articles about 3,9-dimethyl-3,9-di(m-hydroxyphenyl)-2,4,8,10-tetraoxaspiro[5.5]undecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3,9-dimethyl-3,9-di(m-acetyloxyphenyl)-2,4,8,10-tetraoxaspiro[5.5]undecane → 3,9-dimethyl-3,9-di(m-hydroxyphenyl)-2,4,8,10-tetraoxaspiro[5.5]undecane (726173-39-3)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 12h;

DOI:10.1016/j.tet.2004.04.002

Reference yield:

Pentaerythritol (115-77-5) → 3,9-dimethyl-3,9-di(m-hydroxyphenyl)-2,4,8,10-tetraoxaspiro[5.5]undecane (726173-39-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 49 percent / p-toluenesulfonic acid / toluene / Heating

2: 93 percent / aq. LiOH / methanol; tetrahydrofuran / 12 h / 20 °C

With lithium hydroxide; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; toluene;

DOI:10.1016/j.tet.2004.04.002

Reference yield: 17.0%

triethylene glycol di-(p-toluenesulfonate) (19249-03-7) + 3,9-dimethyl-3,9-di(m-hydroxyphenyl)-2,4,8,10-tetraoxaspiro[5.5]undecane (726173-39-3) → 17,23-dimethyl-2,5,8,11,18,22,29,32-octaoxapentacyclo[22.3.217,20.220,23.11,24.112,16]tritriaconta-1(33),12,14,16(28),24,26-hexaene + 17,23,44,50-tetramethyl-2,5,8,11,18,22,29,32,35,38,45,49,56,59,62,65-hexadecaoxanonacyclo[49.3.217,20.220,23.244,47.247,50.11,51.112,16.124,28.139,43]hexahexaconta-1(66),12,14,16(55),24,26,28(60),39,41,43(61),51,53-dodecaene

Guidance literature:

3,9-dimethyl-3,9-di(m-hydroxyphenyl)-2,4,8,10-tetraoxaspiro[5.5]undecane; With caesium carbonate; In acetonitrile; for 7h; Heating;

triethylene glycol di-(p-toluenesulfonate); In acetonitrile; for 120h; Further stages.; Heating;

DOI:10.1016/j.tet.2004.04.002

upstream raw materials:

Pentaerythritol