2-[[7-[[dimethyl(oxo)-λ⁶-sulfanylidene]amino]-5-methyl-quinazolin-4-yl]amino]-5-fluoro-phenol

Base Information

• Chemical Name: 2-[[7-[[dimethyl(oxo)-λ⁶-sulfanylidene]amino]-5-methyl-quinazolin-4-yl]amino]-5-fluoro-phenol
• CAS No.: 1609963-61-2
• Molecular Formula: C₁₇H₁₇FN₄O₂S
• Molecular Weight: 360.412

Synonyms:2-[[7-[[dimethyl(oxo)-λ⁶-sulfanylidene]amino]-5-methyl-quinazolin-4-yl]amino]-5-fluoro-phenol

Chemical Property of 2-[[7-[[dimethyl(oxo)-λ⁶-sulfanylidene]amino]-5-methyl-quinazolin-4-yl]amino]-5-fluoro-phenol

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 2-[[7-[[dimethyl(oxo)-λ⁶-sulfanylidene]amino]-5-methyl-quinazolin-4-yl]amino]-5-fluoro-phenol

There total 4 articles about 2-[[7-[[dimethyl(oxo)-λ⁶-sulfanylidene]amino]-5-methyl-quinazolin-4-yl]amino]-5-fluoro-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

N-(2-benzyloxy-4-fluoro-phenyl)-7-[[dimethyl(oxo)-λ6-sulfanylidene]amino]-5-methyl-quinazolin-4-amine (1609963-63-4) → 2-[[7-[[dimethyl(oxo)-λ6-sulfanylidene]amino]-5-methyl-quinazolin-4-yl]amino]-5-fluoro-phenol (1609963-61-2)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 ℃; for 0.25h;

Reference yield:

N-(2-benzyloxy-4-fluoro-phenyl)-7-bromo-5-methyl-quinazolin-4-amine (1609963-62-3) → 2-[[7-[[dimethyl(oxo)-λ6-sulfanylidene]amino]-5-methyl-quinazolin-4-yl]amino]-5-fluoro-phenol (1609963-61-2)

Guidance literature:

Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos; sodium t-butanolate / 1,4-dioxane / 4.5 h / 80 °C

2: boron tribromide / dichloromethane / 0.25 h / 0 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; boron tribromide; johnphos; sodium t-butanolate; In 1,4-dioxane; dichloromethane;

Reference yield:

C11H12BrN3 (1609962-88-0) → 2-[[7-[[dimethyl(oxo)-λ6-sulfanylidene]amino]-5-methyl-quinazolin-4-yl]amino]-5-fluoro-phenol (1609963-61-2)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / 1 h / 100 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos; sodium t-butanolate / 1,4-dioxane / 4.5 h / 80 °C

3: boron tribromide / dichloromethane / 0.25 h / 0 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; boron tribromide; johnphos; sodium t-butanolate; In 1,4-dioxane; dichloromethane; acetic acid;

upstream raw materials:

N-(2-benzyloxy-4-fluoro-phenyl)-7-bromo-5-methyl-quinazolin-4-amine

N-(2-benzyloxy-4-fluoro-phenyl)-7-[[dimethyl(oxo)-λ⁶-sulfanylidene]amino]-5-methyl-quinazolin-4-amine

C₁₁H₁₂BrN₃

2-(benzyloxy)-4-fluoroaniline

Downstream raw materials:

C₂₀H₂₂FN₅O₃S

tert-butyl 4-[2-[[7-[[dimethyl(oxo)-λ⁶-sulfanylidene]amino]-5-methyl-quinazolin-4-yl]amino]-5-fluorophenoxy]isoxazolidine-2-carboxylate trifluoroacetic acid

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