2-Methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid {2-chloro-5-[1-(3-chloro-phenyl)-3-dimethylamino-propylcarbamoyl]-phenyl}-amide

Base Information

• Chemical Name: 2-Methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid {2-chloro-5-[1-(3-chloro-phenyl)-3-dimethylamino-propylcarbamoyl]-phenyl}-amide
• CAS No.: 1386979-89-0
• Molecular Formula: C₂₇H₂₆Cl₂N₆O₄
• Molecular Weight: 569.447
• Mol file: 1386979-89-0.mol

Synonyms:2-Methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid {2-chloro-5-[1-(3-chloro-phenyl)-3-dimethylamino-propylcarbamoyl]-phenyl}-amide

Chemical Property of 2-Methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid {2-chloro-5-[1-(3-chloro-phenyl)-3-dimethylamino-propylcarbamoyl]-phenyl}-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid {2-chloro-5-[1-(3-chloro-phenyl)-3-dimethylamino-propylcarbamoyl]-phenyl}-amide

There total 9 articles about 2-Methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid {2-chloro-5-[1-(3-chloro-phenyl)-3-dimethylamino-propylcarbamoyl]-phenyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.2%

4-chloro-3-[(2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-benzoic acid (1386980-75-1) + C11H17ClN2 (1250209-32-5) → 2-Methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid {2-chloro-5-[1-(3-chloro-phenyl)-3-dimethylamino-propylcarbamoyl]-phenyl}-amide (1386979-89-0)

Guidance literature:

4-chloro-3-[(2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-benzoic acid; With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

C₁₁H₁₇ClN₂; In N,N-dimethyl-formamide; for 18h;

Reference yield:

2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid (1386980-73-9) → 2-Methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid {2-chloro-5-[1-(3-chloro-phenyl)-3-dimethylamino-propylcarbamoyl]-phenyl}-amide (1386979-89-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

2.1: sodium hydroxide; water / methanol / 18 h / 65 °C

3.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 18 h

With water; triethylamine; HATU; sodium hydroxide; In methanol; N,N-dimethyl-formamide;

Reference yield:

4-chloro-3-[(2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-benzoic acid methyl ester (1386979-05-0) → 2-Methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid {2-chloro-5-[1-(3-chloro-phenyl)-3-dimethylamino-propylcarbamoyl]-phenyl}-amide (1386979-89-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / methanol / 18 h / 65 °C

2.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 18 h

With water; triethylamine; HATU; sodium hydroxide; In methanol; N,N-dimethyl-formamide;

upstream raw materials:

2-(3-chlorobenzoyl)-N,N-dimethylethylamine hydrochloride

3'-Chloroacetophenone

4-chloro-3-[(2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-benzoic acid methyl ester

4-chloro-3-[(2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-benzoic acid