N-(N-1-4,4'-dimethoxytrityl-biotinyl)-O-4,4'-dimethoxytrityl-6-hydroxyhexyl D,L-serine amide

Base Information

Chemical Name:N-(N-1-4,4'-dimethoxytrityl-biotinyl)-O-4,4'-dimethoxytrityl-6-hydroxyhexyl D,L-serine amide
CAS No.:244214-18-4
Molecular Formula:C₆₁H₇₀N₄O₉S
Molecular Weight:1035.31
Hs Code.:

Synonyms:N-(N-1-4,4'-dimethoxytrityl-biotinyl)-O-4,4'-dimethoxytrityl-6-hydroxyhexyl D,L-serine amide

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Chemical Property of N-(N-1-4,4'-dimethoxytrityl-biotinyl)-O-4,4'-dimethoxytrityl-6-hydroxyhexyl D,L-serine amide

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Technology Process of N-(N-1-4,4'-dimethoxytrityl-biotinyl)-O-4,4'-dimethoxytrityl-6-hydroxyhexyl D,L-serine amide

There total 8 articles about N-(N-1-4,4'-dimethoxytrityl-biotinyl)-O-4,4'-dimethoxytrityl-6-hydroxyhexyl D,L-serine amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 244214-17-3
5-{1-[bis-(4-methoxy-phenyl)-phenyl-methyl]-2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl}-pentanoic acid {2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-[6-(tert-butyl-dimethyl-silanyloxy)-hexylcarbamoyl]-ethyl}-amide

: 244214-18-4
N-(N-1-4,4'-dimethoxytrityl-biotinyl)-O-4,4'-dimethoxytrityl-6-hydroxyhexyl D,L-serine amide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 1h;
DOI:10.1080/07328319908044672

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 244214-18-4
N-(N-1-4,4'-dimethoxytrityl-biotinyl)-O-4,4'-dimethoxytrityl-6-hydroxyhexyl D,L-serine amide

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine

2: 94 percent / aq. NaOH / methanol

3: 61 percent / DEC / pyridine

4: 86 percent / DMAP / pyridine / Heating

5: 86 percent / TBAF / tetrahydrofuran / 1 h

With pyridine; dmap; sodium hydroxide; diethylcarbamazine; tetrabutyl ammonium fluoride; In tetrahydrofuran; pyridine; methanol; 1: Etherification / 2: Hydrolysis / 3: Substitution / 4: Substitution / 5: Hydrolysis;
DOI:10.1080/07328319908044672

Reference yield:

: 35013-72-0
biotin N-Hydroxysuccinimide ester

: 244214-18-4
N-(N-1-4,4'-dimethoxytrityl-biotinyl)-O-4,4'-dimethoxytrityl-6-hydroxyhexyl D,L-serine amide

Guidance literature:: Multi-step reaction with 6 steps

1: DIPEA / dimethylformamide

2: pyridine

3: 94 percent / aq. NaOH / methanol

4: 61 percent / DEC / pyridine

5: 86 percent / DMAP / pyridine / Heating

6: 86 percent / TBAF / tetrahydrofuran / 1 h

With pyridine; dmap; sodium hydroxide; diethylcarbamazine; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; pyridine; methanol; N,N-dimethyl-formamide; 1: Substitution / 2: Etherification / 3: Hydrolysis / 4: Substitution / 5: Substitution / 6: Hydrolysis;
DOI:10.1080/07328319908044672