((2S,3S)-3-bromo-2-(4-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-2-yl)(4-(trifluoromethyl)phenyl)methanone

Base Information

Chemical Name:((2S,3S)-3-bromo-2-(4-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-2-yl)(4-(trifluoromethyl)phenyl)methanone
CAS No.:1307863-05-3
Molecular Formula:C₂₀H₁₅BrF₆O₂
Molecular Weight:481.232
Hs Code.:

Synonyms:((2S,3S)-3-bromo-2-(4-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-2-yl)(4-(trifluoromethyl)phenyl)methanone

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Chemical Property of ((2S,3S)-3-bromo-2-(4-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-2-yl)(4-(trifluoromethyl)phenyl)methanone

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Technology Process of ((2S,3S)-3-bromo-2-(4-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-2-yl)(4-(trifluoromethyl)phenyl)methanone

There total 4 articles about ((2S,3S)-3-bromo-2-(4-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-2-yl)(4-(trifluoromethyl)phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1307862-93-6
C₂₀H₁₆F₆O₂

: 1307863-05-3
((2S,3S)-3-bromo-2-(4-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-2-yl)(4-(trifluoromethyl)phenyl)methanone

Guidance literature:: With hydroquinindine-2,5-diphenyl-4,6-pyrimidinediyl diether; (2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid; N-bromoacetamide; In tetrachloromethane; at 0 ℃; optical yield given as %ee; enantioselective reaction; Molecular sieve;
DOI:10.1021/ja201794v

Reference yield:

: 1307862-93-6
C₂₀H₁₆F₆O₂

: 1307863-05-3
((2S,3S)-3-bromo-2-(4-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-2-yl)(4-(trifluoromethyl)phenyl)methanone

: 1307863-18-8
((2R,3R)-3-bromo-2-(4-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-2-yl)(4-(trifluoromethyl)phenyl)methanone

Guidance literature:: With (8a,9R,8′′′a,9′′′R)-9,9′-[(2,5-diphenylpyrimidine-4,6-diyl)bis(oxy)]bis(6′-methoxy-10,11-dihydrocinchonan); Boc-D-Phg-OH; N-bromoacetamide; In toluene; at -10 ℃; optical yield given as %ee; enantioselective reaction; Molecular sieve;
DOI:10.1021/ja201794v

Reference yield:

: 21221-91-0
4,4'-bis(trifluoromethyl)benzophenone

: 1307863-05-3
((2S,3S)-3-bromo-2-(4-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-2-yl)(4-(trifluoromethyl)phenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 3 h / 0 - 20 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: hydroquinindine-2,5-diphenyl-4,6-pyrimidinediyl diether; (2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid; N-bromoacetamide / tetrachloromethane / 0 °C / Molecular sieve

With n-butyllithium; hydroquinindine-2,5-diphenyl-4,6-pyrimidinediyl diether; (2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid; N-bromoacetamide; In tetrahydrofuran; tetrachloromethane; hexane;
DOI:10.1021/ja201794v