dimethyl ((1R,1′R) -((2S,2′S)-2,2'-(((ethyne-1,2-diylbis(4,1-phenylene)) bis(azanediyl))bis(carbonyl)) bis(pyrrolidine-2,1-diyl)) bis(2-oxo-1-phenylethane-2,1-diyl)) dicarbamate

Base Information

Chemical Name:dimethyl ((1R,1′R) -((2S,2′S)-2,2'-(((ethyne-1,2-diylbis(4,1-phenylene)) bis(azanediyl))bis(carbonyl)) bis(pyrrolidine-2,1-diyl)) bis(2-oxo-1-phenylethane-2,1-diyl)) dicarbamate
CAS No.:1219632-37-7
Molecular Formula:C₄₄H₄₄N₆O₈
Molecular Weight:784.869
Hs Code.:

dimethyl ((1R,1′R) -((2S,2′S)-2,2'-(((ethyne-1,2-diylbis(4,1-phenylene)) bis(azanediyl))bis(carbonyl)) bis(pyrrolidine-2,1-diyl)) bis(2-oxo-1-phenylethane-2,1-diyl)) dicarbamate

Synonyms:dimethyl ((1R,1′R) -((2S,2′S)-2,2'-(((ethyne-1,2-diylbis(4,1-phenylene)) bis(azanediyl))bis(carbonyl)) bis(pyrrolidine-2,1-diyl)) bis(2-oxo-1-phenylethane-2,1-diyl)) dicarbamate

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Chemical Property of dimethyl ((1R,1′R) -((2S,2′S)-2,2'-(((ethyne-1,2-diylbis(4,1-phenylene)) bis(azanediyl))bis(carbonyl)) bis(pyrrolidine-2,1-diyl)) bis(2-oxo-1-phenylethane-2,1-diyl)) dicarbamate

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Technology Process of dimethyl ((1R,1′R) -((2S,2′S)-2,2'-(((ethyne-1,2-diylbis(4,1-phenylene)) bis(azanediyl))bis(carbonyl)) bis(pyrrolidine-2,1-diyl)) bis(2-oxo-1-phenylethane-2,1-diyl)) dicarbamate

There total 6 articles about dimethyl ((1R,1′R) -((2S,2′S)-2,2'-(((ethyne-1,2-diylbis(4,1-phenylene)) bis(azanediyl))bis(carbonyl)) bis(pyrrolidine-2,1-diyl)) bis(2-oxo-1-phenylethane-2,1-diyl)) dicarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: N,N’-(ethyne-1,2-diylbis (4,1-phenylene))bis(pyrrolidine-2-carboxamide)

: 50890-96-5
(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetic acid

: 1219632-37-7
dimethyl ((1R,1′R) -((2S,2′S)-2,2'-(((ethyne-1,2-diylbis(4,1-phenylene)) bis(azanediyl))bis(carbonyl)) bis(pyrrolidine-2,1-diyl)) bis(2-oxo-1-phenylethane-2,1-diyl)) dicarbamate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; at 25 - 30 ℃; for 24h;
DOI:10.1016/j.ejmech.2021.114034

Reference yield:

: C₂₁H₂₂BrN₃O₄

: 2117-50-2
bis(trimethyltin)acetylene

: 1219632-37-7
dimethyl ((1R,1′R) -((2S,2′S)-2,2'-(((ethyne-1,2-diylbis(4,1-phenylene)) bis(azanediyl))bis(carbonyl)) bis(pyrrolidine-2,1-diyl)) bis(2-oxo-1-phenylethane-2,1-diyl)) dicarbamate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 80 ℃;
DOI:10.1016/j.bmcl.2013.05.040

Reference yield:

: 1219632-33-3
C₂₄H₂₈BrN₃O₄

: 1219632-37-7
dimethyl ((1R,1′R) -((2S,2′S)-2,2'-(((ethyne-1,2-diylbis(4,1-phenylene)) bis(azanediyl))bis(carbonyl)) bis(pyrrolidine-2,1-diyl)) bis(2-oxo-1-phenylethane-2,1-diyl)) dicarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane

2: triethylamine / tetrahydrofuran

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 80 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; 3: |Stille Cross Coupling;
DOI:10.1016/j.bmcl.2013.05.040