(E)-3-{3-[3-(2,2-Dimethyl-propionylamino)-5-ethyl-2-methoxy-6-methyl-pyridine-4-carbonyl]-phenyl}-acrylic acid ethyl ester

Base Information

Chemical Name:(E)-3-{3-[3-(2,2-Dimethyl-propionylamino)-5-ethyl-2-methoxy-6-methyl-pyridine-4-carbonyl]-phenyl}-acrylic acid ethyl ester
CAS No.:796863-83-7
Molecular Formula:C₂₆H₃₂N₂O₅
Molecular Weight:452.55
Hs Code.:

Synonyms:(E)-3-{3-[3-(2,2-Dimethyl-propionylamino)-5-ethyl-2-methoxy-6-methyl-pyridine-4-carbonyl]-phenyl}-acrylic acid ethyl ester

Suppliers and Price of (E)-3-{3-[3-(2,2-Dimethyl-propionylamino)-5-ethyl-2-methoxy-6-methyl-pyridine-4-carbonyl]-phenyl}-acrylic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-3-{3-[3-(2,2-Dimethyl-propionylamino)-5-ethyl-2-methoxy-6-methyl-pyridine-4-carbonyl]-phenyl}-acrylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-3-{3-[3-(2,2-Dimethyl-propionylamino)-5-ethyl-2-methoxy-6-methyl-pyridine-4-carbonyl]-phenyl}-acrylic acid ethyl ester

There total 5 articles about (E)-3-{3-[3-(2,2-Dimethyl-propionylamino)-5-ethyl-2-methoxy-6-methyl-pyridine-4-carbonyl]-phenyl}-acrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 796863-79-1
N-[5-ethyl-4-(3-formylbenzoyl)-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropionamide

: 796863-83-7
(E)-3-{3-[3-(2,2-Dimethyl-propionylamino)-5-ethyl-2-methoxy-6-methyl-pyridine-4-carbonyl]-phenyl}-acrylic acid ethyl ester

Guidance literature:: diethoxyphosphoryl-acetic acid ethyl ester; With potassium tert-butylate; In tetrahydrofuran; at 5 ℃; for 0.5h;

N-[5-ethyl-4-(3-formylbenzoyl)-2-methoxy-6-methylpyridin-3-yl]-2,2-dimethylpropionamide; In tetrahydrofuran; at 5 ℃; for 1h;
DOI:10.1021/jm0407658

Reference yield:

: 68348-23-2
3-(1,3-dioxolan-2-yl)benzaldehyde

: 796863-83-7
(E)-3-{3-[3-(2,2-Dimethyl-propionylamino)-5-ethyl-2-methoxy-6-methyl-pyridine-4-carbonyl]-phenyl}-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium; TMEDA / tetrahydrofuran; hexane / -78 - 0 °C

1.2: 69 percent / tetrahydrofuran; hexane / -78 - 0 °C

2.1: 73 percent / tri[2-(2-methoxyethoxy)ethyl]amine; KMnO₄ / CH₂Cl₂ / 12 h / 20 °C

3.1: 100 percent / aq. HCl / 1 h / 20 °C

4.1: potassium tert-butoxide / tetrahydrofuran / 0.5 h / 5 °C

4.2: 75 percent / tetrahydrofuran / 1 h / 5 °C

With hydrogenchloride; potassium permanganate; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; Tris(3,6-dioxaheptyl)amine; potassium tert-butylate; In tetrahydrofuran; hexane; dichloromethane; 4.2: Wittig-Horner reaction;
DOI:10.1021/jm0407658

Reference yield:

: 197229-98-4
5-ethyl-2-methoxy-6-methyl-3-pivaloylaminopyridine

: 796863-83-7
(E)-3-{3-[3-(2,2-Dimethyl-propionylamino)-5-ethyl-2-methoxy-6-methyl-pyridine-4-carbonyl]-phenyl}-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium; TMEDA / tetrahydrofuran; hexane / -78 - 0 °C

1.2: 69 percent / tetrahydrofuran; hexane / -78 - 0 °C

2.1: 73 percent / tri[2-(2-methoxyethoxy)ethyl]amine; KMnO₄ / CH₂Cl₂ / 12 h / 20 °C

3.1: 100 percent / aq. HCl / 1 h / 20 °C

4.1: potassium tert-butoxide / tetrahydrofuran / 0.5 h / 5 °C

4.2: 75 percent / tetrahydrofuran / 1 h / 5 °C

With hydrogenchloride; potassium permanganate; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; Tris(3,6-dioxaheptyl)amine; potassium tert-butylate; In tetrahydrofuran; hexane; dichloromethane; 4.2: Wittig-Horner reaction;
DOI:10.1021/jm0407658