(S)-1-(2-Hydroxy-4,5-dimethoxybenzyl)-2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin

Base Information

• Chemical Name: (S)-1-(2-Hydroxy-4,5-dimethoxybenzyl)-2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin
• CAS No.: 4829-27-0
• Molecular Formula: C₂₁H₂₇NO₅
• Molecular Weight: 373.449
• Mol file: 4829-27-0.mol

Synonyms:(S)-1-(2-Hydroxy-4,5-dimethoxybenzyl)-2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin

Chemical Property of (S)-1-(2-Hydroxy-4,5-dimethoxybenzyl)-2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-(2-Hydroxy-4,5-dimethoxybenzyl)-2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin

There total 5 articles about (S)-1-(2-Hydroxy-4,5-dimethoxybenzyl)-2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(+)-O,O-Dimethylmalekulatine (87183-79-7) → (S)-1-(2-Hydroxy-4,5-dimethoxybenzyl)-2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin (4829-27-0) + (S)-1-(3,4-Dimethoxy-benzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline (87246-83-1)

Guidance literature:

With ammonia; sodium; In tetrahydrofuran; 1) -78 degC, 0.5-2 h, 2) warm to room temp.;

DOI:10.1021/jo00170a016

Reference yield: 70.0%

(+)-O,O-Dimethylvanuatine (87183-77-5) → (S)-1-(2-Hydroxy-4,5-dimethoxybenzyl)-2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin (4829-27-0) + (R)-(-)-O-methylarmepavine (3423-02-7,13425-06-4)

Guidance literature:

In tetrahydrofuran; 1) -78 degC, 0.5-2 h, 2) warm to room temp.;

DOI:10.1021/jo00170a016

Reference yield:

(+)-Vanuatine (87183-74-2) → (S)-1-(2-Hydroxy-4,5-dimethoxybenzyl)-2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin (4829-27-0)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether; methanol / 24 h / refrigerator

2: 70 percent / tetrahydrofuran / 1) -78 degC, 0.5-2 h, 2) warm to room temp.

In tetrahydrofuran; methanol; diethyl ether;

DOI:10.1021/jo00170a016

upstream raw materials:

(+)-O,O-Dimethylmalekulatine

(+)-O,O-Dimethylvanuatine

(+)-Malekulatine

(+)-Vanuatine