N-[(2R)-3-phenyl-1-pivaloyloxy-2-propyl]-N'-[(R)-α-methyl-4-aminobenzyl]thiourea

Base Information

Chemical Name:N-[(2R)-3-phenyl-1-pivaloyloxy-2-propyl]-N'-[(R)-α-methyl-4-aminobenzyl]thiourea
CAS No.:824937-62-4
Molecular Formula:C₂₃H₃₁N₃O₂S
Molecular Weight:413.584
Hs Code.:

Synonyms:N-[(2R)-3-phenyl-1-pivaloyloxy-2-propyl]-N'-[(R)-α-methyl-4-aminobenzyl]thiourea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(2R)-3-phenyl-1-pivaloyloxy-2-propyl]-N'-[(R)-α-methyl-4-aminobenzyl]thiourea

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Technology Process of N-[(2R)-3-phenyl-1-pivaloyloxy-2-propyl]-N'-[(R)-α-methyl-4-aminobenzyl]thiourea

There total 11 articles about N-[(2R)-3-phenyl-1-pivaloyloxy-2-propyl]-N'-[(R)-α-methyl-4-aminobenzyl]thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 824937-61-3
N-[(2R)-3-phenyl-1-pivaloyloxy-2-propyl]-N'-[(R)-α-methyl-4-nitrobenzyl]thiourea

: 824937-62-4
N-[(2R)-3-phenyl-1-pivaloyloxy-2-propyl]-N'-[(R)-α-methyl-4-aminobenzyl]thiourea

Guidance literature:: With potassium hydroxide; aluminium; In water;

With mercury dichloride; In water;

N-[(2R)-3-phenyl-1-pivaloyloxy-2-propyl]-N'-[(R)-α-methyl-4-nitrobenzyl]thiourea; water; In diethyl ether; for 0.5h; Heating / reflux;

Reference yield:

: 5267-64-1
(R)-2-amino-3-phenylpropanol

: 824937-62-4
N-[(2R)-3-phenyl-1-pivaloyloxy-2-propyl]-N'-[(R)-α-methyl-4-aminobenzyl]thiourea

Guidance literature:: Multi-step reaction with 5 steps

1.1: dichloromethane / 20 °C

2.1: triethylamine / dichloromethane / 0 °C

3.1: trifluoroacetic acid / dichloromethane / 0 °C

3.2: 50 °C

4.1: triethylamine / dichloromethane

5.1: hydrogen; palladium on activated charcoal / methanol

With palladium on activated charcoal; hydrogen; triethylamine; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2014.04.054

Reference yield:

: C₁₄H₂₁NO₃

: 824937-62-4
N-[(2R)-3-phenyl-1-pivaloyloxy-2-propyl]-N'-[(R)-α-methyl-4-aminobenzyl]thiourea

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 0 °C

2.1: trifluoroacetic acid / dichloromethane / 0 °C

2.2: 50 °C

3.1: triethylamine / dichloromethane

4.1: hydrogen; palladium on activated charcoal / methanol

With palladium on activated charcoal; hydrogen; triethylamine; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2014.04.054