(4aS,6S,7R,7aS)-1-benzyl-6-(tert-butyldiphenylsiloxymethyl)-4a-methoxy-hexahydro-1H-furano[3,2-c][1,2]oxazinan-7-ol

Base Information

Chemical Name:(4aS,6S,7R,7aS)-1-benzyl-6-(tert-butyldiphenylsiloxymethyl)-4a-methoxy-hexahydro-1H-furano[3,2-c][1,2]oxazinan-7-ol
CAS No.:1392007-64-5
Molecular Formula:C₃₁H₃₉NO₅Si
Molecular Weight:533.74
Hs Code.:

Synonyms:(4aS,6S,7R,7aS)-1-benzyl-6-(tert-butyldiphenylsiloxymethyl)-4a-methoxy-hexahydro-1H-furano[3,2-c][1,2]oxazinan-7-ol

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Chemical Property of (4aS,6S,7R,7aS)-1-benzyl-6-(tert-butyldiphenylsiloxymethyl)-4a-methoxy-hexahydro-1H-furano[3,2-c][1,2]oxazinan-7-ol

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Technology Process of (4aS,6S,7R,7aS)-1-benzyl-6-(tert-butyldiphenylsiloxymethyl)-4a-methoxy-hexahydro-1H-furano[3,2-c][1,2]oxazinan-7-ol

There total 3 articles about (4aS,6S,7R,7aS)-1-benzyl-6-(tert-butyldiphenylsiloxymethyl)-4a-methoxy-hexahydro-1H-furano[3,2-c][1,2]oxazinan-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1392007-63-4
(3S,4'R,5'S)-2-benzyl-3-(5'-tert-butyldiphenylsiloxymethyl-2',2'-dimethyl-1',3'-dioxolan-4'-yl)-4-methoxy-3,6-dihydro-2H-[1,2]oxazine

: 1392007-58-7
(4aS,6S,7R,7aS)-1-benzyl-6-hydroxymethyl-4a-methoxy-hexahydro-1H-furano[3,2-c][1,2]oxazine-7-ol

: 1392007-64-5
(4aS,6S,7R,7aS)-1-benzyl-6-(tert-butyldiphenylsiloxymethyl)-4a-methoxy-hexahydro-1H-furano[3,2-c][1,2]oxazinan-7-ol

Guidance literature:: With methanol; p-toluenesulfonyl chloride; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1002/ejoc.201200158

Reference yield:

: (2S,3S,4S)-N-benzyl-N-hydroxy-3,4-isopropylidenedioxytetrahydrofuran-2-amine

: 1392007-64-5
(4aS,6S,7R,7aS)-1-benzyl-6-(tert-butyldiphenylsiloxymethyl)-4a-methoxy-hexahydro-1H-furano[3,2-c][1,2]oxazinan-7-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.08 h / -40 °C / Inert atmosphere

1.2: 8 h / -40 °C / Inert atmosphere

2.1: 1H-imidazole; dmap / dichloromethane / 36 h / 0 - 20 °C / Inert atmosphere

3.1: methanol; p-toluenesulfonyl chloride / 18 h / 20 °C / Inert atmosphere

With 1H-imidazole; methanol; dmap; n-butyllithium; p-toluenesulfonyl chloride; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1002/ejoc.201200158

Reference yield:

: 1392007-21-4
(3S,4'R,5'S)-2-benzyl-3-(5'-hydroxymethyl-2',2'-dimethyl-1',3'-dioxolan-4'-yl)-4-methoxy-3,6-dihydro-2H-[1,2]oxazine

: 1392007-64-5
(4aS,6S,7R,7aS)-1-benzyl-6-(tert-butyldiphenylsiloxymethyl)-4a-methoxy-hexahydro-1H-furano[3,2-c][1,2]oxazinan-7-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole; dmap / dichloromethane / 36 h / 0 - 20 °C / Inert atmosphere

2: methanol; p-toluenesulfonyl chloride / 18 h / 20 °C / Inert atmosphere

With 1H-imidazole; methanol; dmap; p-toluenesulfonyl chloride; In dichloromethane;
DOI:10.1002/ejoc.201200158