2-[(2R,3S)-2-Acetylsulfanyl-4-oxo-3-(2-oxo-propyl)-3-phenylsulfanyl-azetidin-1-yl]-3-methyl-but-2-enoic acid 2,2-dimethyl-propionyloxymethyl ester

Base Information

Chemical Name:2-[(2R,3S)-2-Acetylsulfanyl-4-oxo-3-(2-oxo-propyl)-3-phenylsulfanyl-azetidin-1-yl]-3-methyl-but-2-enoic acid 2,2-dimethyl-propionyloxymethyl ester
CAS No.:92826-86-3
Molecular Formula:C₂₅H₃₁NO₇S₂
Molecular Weight:521.656
Hs Code.:

2-[(2R,3S)-2-Acetylsulfanyl-4-oxo-3-(2-oxo-propyl)-3-phenylsulfanyl-azetidin-1-yl]-3-methyl-but-2-enoic acid 2,2-dimethyl-propionyloxymethyl ester

Synonyms:2-[(2R,3S)-2-Acetylsulfanyl-4-oxo-3-(2-oxo-propyl)-3-phenylsulfanyl-azetidin-1-yl]-3-methyl-but-2-enoic acid 2,2-dimethyl-propionyloxymethyl ester

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Chemical Property of 2-[(2R,3S)-2-Acetylsulfanyl-4-oxo-3-(2-oxo-propyl)-3-phenylsulfanyl-azetidin-1-yl]-3-methyl-but-2-enoic acid 2,2-dimethyl-propionyloxymethyl ester

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Technology Process of 2-[(2R,3S)-2-Acetylsulfanyl-4-oxo-3-(2-oxo-propyl)-3-phenylsulfanyl-azetidin-1-yl]-3-methyl-but-2-enoic acid 2,2-dimethyl-propionyloxymethyl ester

There total 6 articles about 2-[(2R,3S)-2-Acetylsulfanyl-4-oxo-3-(2-oxo-propyl)-3-phenylsulfanyl-azetidin-1-yl]-3-methyl-but-2-enoic acid 2,2-dimethyl-propionyloxymethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 108-24-7
acetic anhydride

: 92826-85-2
2-[(2R,3S)-2-(Benzothiazol-2-yldisulfanyl)-4-oxo-3-(2-oxo-propyl)-3-phenylsulfanyl-azetidin-1-yl]-3-methyl-but-2-enoic acid 2,2-dimethyl-propionyloxymethyl ester

: 92826-86-3
2-[(2R,3S)-2-Acetylsulfanyl-4-oxo-3-(2-oxo-propyl)-3-phenylsulfanyl-azetidin-1-yl]-3-methyl-but-2-enoic acid 2,2-dimethyl-propionyloxymethyl ester

Guidance literature:: With pyridine; triphenylphosphine; In acetic acid; at -20 ℃;

Reference yield:

: 108-98-5
thiophenol

: 92826-86-3
2-[(2R,3S)-2-Acetylsulfanyl-4-oxo-3-(2-oxo-propyl)-3-phenylsulfanyl-azetidin-1-yl]-3-methyl-but-2-enoic acid 2,2-dimethyl-propionyloxymethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 30 percent / DBN / CH₂Cl₂ / 20 °C

2: 100 percent / toluene / Heating

3: Et₃N / CH₂Cl₂ / 4 h / 20 °C

4: 73 percent / triphenylphosphine, pyridine / acetic acid / -20 °C

With pyridine; 2,6-dichloro-benzonitrile; triethylamine; triphenylphosphine; In dichloromethane; acetic acid; toluene;

Reference yield:

: 83137-22-8
methylene (6Z)-6-acetonylidenepenicillanate pivalate

: 92826-86-3
2-[(2R,3S)-2-Acetylsulfanyl-4-oxo-3-(2-oxo-propyl)-3-phenylsulfanyl-azetidin-1-yl]-3-methyl-but-2-enoic acid 2,2-dimethyl-propionyloxymethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / m-chloroperbenzoic acid / tetrahydrofuran / 20 °C

2: 30 percent / DBN / CH₂Cl₂ / 20 °C

3: 100 percent / toluene / Heating

4: Et₃N / CH₂Cl₂ / 4 h / 20 °C

5: 73 percent / triphenylphosphine, pyridine / acetic acid / -20 °C

With pyridine; 2,6-dichloro-benzonitrile; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In tetrahydrofuran; dichloromethane; acetic acid; toluene;