4-{3-[3-(4-hydroxyphenyl)-4-ethylisoxazol-5-yl]propanoyl}amino-1-ethylpyrrole-3-carboxylic acid

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Chemical Name:4-{3-[3-(4-hydroxyphenyl)-4-ethylisoxazol-5-yl]propanoyl}amino-1-ethylpyrrole-3-carboxylic acid
CAS No.:1204422-36-5
Molecular Formula:C₂₁H₂₃N₃O₅
Molecular Weight:397.431
Hs Code.:

Synonyms:4-{3-[3-(4-hydroxyphenyl)-4-ethylisoxazol-5-yl]propanoyl}amino-1-ethylpyrrole-3-carboxylic acid

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Chemical Property of 4-{3-[3-(4-hydroxyphenyl)-4-ethylisoxazol-5-yl]propanoyl}amino-1-ethylpyrrole-3-carboxylic acid

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Technology Process of 4-{3-[3-(4-hydroxyphenyl)-4-ethylisoxazol-5-yl]propanoyl}amino-1-ethylpyrrole-3-carboxylic acid

There total 6 articles about 4-{3-[3-(4-hydroxyphenyl)-4-ethylisoxazol-5-yl]propanoyl}amino-1-ethylpyrrole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1204423-64-2
C₃₅H₃₃N₃O₅

: 1204422-36-5
4-{3-[3-(4-hydroxyphenyl)-4-ethylisoxazol-5-yl]propanoyl}amino-1-ethylpyrrole-3-carboxylic acid

Guidance literature:: With hydrogen; 20% palladium(II) hydroxide on carbon; In tetrahydrofuran; ethanol; at 20 ℃; for 5h;

Reference yield:

: 84284-70-8
[4-(benzyloxy)phenyl]acetylene

: 1204422-36-5
4-{3-[3-(4-hydroxyphenyl)-4-ethylisoxazol-5-yl]propanoyl}amino-1-ethylpyrrole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine; 1,4-diisocyanatobenzene / toluene / 6 h / 110 °C

2: N-Bromosuccinimide / N,N-dimethyl-formamide / 5.5 h / 20 °C

3: sodium hydroxide; water / tetrahydrofuran; methanol / 1.5 h / 60 °C

4: triethylamine; HATU / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

5: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; ISOPROPYLAMIDE / 1 h / 130 °C

6: hydrogen / 20% palladium(II) hydroxide on carbon / ethanol; tetrahydrofuran / 5 h / 20 °C

With N-Bromosuccinimide; water; hydrogen; sodium carbonate; 1,4-diisocyanatobenzene; triethylamine; HATU; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 20% palladium(II) hydroxide on carbon; In tetrahydrofuran; methanol; ethanol; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1204423-61-9
C₁₉H₁₆BrNO₄

: 1204422-36-5
4-{3-[3-(4-hydroxyphenyl)-4-ethylisoxazol-5-yl]propanoyl}amino-1-ethylpyrrole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; HATU / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; ISOPROPYLAMIDE / 1 h / 130 °C

3: hydrogen / 20% palladium(II) hydroxide on carbon / ethanol; tetrahydrofuran / 5 h / 20 °C

With hydrogen; sodium carbonate; triethylamine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 20% palladium(II) hydroxide on carbon; In tetrahydrofuran; ethanol; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide;