(R)-tert-butyl 3-benzyl-4-(3-(2-(2-formylphenoxy)phenyl)propanoyl)piperazine-1-carboxylate

Base Information

• Chemical Name: (R)-tert-butyl 3-benzyl-4-(3-(2-(2-formylphenoxy)phenyl)propanoyl)piperazine-1-carboxylate
• CAS No.: 952568-45-5
• Molecular Formula: C₃₂H₃₆N₂O₅
• Molecular Weight: 528.648

Synonyms:(R)-tert-butyl 3-benzyl-4-(3-(2-(2-formylphenoxy)phenyl)propanoyl)piperazine-1-carboxylate

Chemical Property of (R)-tert-butyl 3-benzyl-4-(3-(2-(2-formylphenoxy)phenyl)propanoyl)piperazine-1-carboxylate

Chemical Property:

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Technology Process of (R)-tert-butyl 3-benzyl-4-(3-(2-(2-formylphenoxy)phenyl)propanoyl)piperazine-1-carboxylate

There total 1 articles about (R)-tert-butyl 3-benzyl-4-(3-(2-(2-formylphenoxy)phenyl)propanoyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-tert-butyl 3-benzyl-4-(3-(2-hydroxyphenyl)propanoyl)piperazine-1-carboxylate (952568-51-3) + 2-Fluorobenzaldehyde (446-52-6) → (R)-tert-butyl 3-benzyl-4-(3-(2-(2-formylphenoxy)phenyl)propanoyl)piperazine-1-carboxylate (952568-45-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 12h; Inert atmosphere;

Reference yield: 100.0%

nitromethane (75-52-5) + (R)-tert-butyl 3-benzyl-4-(3-(2-(2-formylphenoxy)phenyl)propanoyl)piperazine-1-carboxylate (952568-45-5) → (R,E)-tert-butyl 3-benzyl-4-(3-(2-(2-(2-nitrovinyl)phenoxy)phenyl)propanoyl)-piperazine-1-carboxylate (952568-47-7)

Guidance literature:

With ammonium acetate; at 80 ℃; for 0.5h; Inert atmosphere;

Reference yield: 91.0%

(R)-tert-butyl 3-benzyl-4-(3-(2-(2-formylphenoxy)phenyl)propanoyl)piperazine-1-carboxylate (952568-45-5) + cyanomethylene triphenylphosphorane (16640-68-9) → (R,E)-tert-butyl 3-benzyl-4-(3-(2-(2-(2-cyanovinyl)phenoxy)phenyl)propanoyl)piperazine-1-carboxylate (952568-54-6)

Guidance literature:

In toluene; at 90 ℃; for 2h; Inert atmosphere;

upstream raw materials:

(R)-tert-butyl 3-benzyl-4-(3-(2-hydroxyphenyl)propanoyl)piperazine-1-carboxylate

2-Fluorobenzaldehyde

Downstream raw materials:

(R,E)-tert-butyl 3-benzyl-4-(3-(2-(2-(2-nitrovinyl)phenoxy)phenyl)propanoyl)-piperazine-1-carboxylate

(R,E)-tert-butyl 3-benzyl-4-(3-(2-(2-(2-cyanovinyl)phenoxy)phenyl)propanoyl)piperazine-1-carboxylate

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