2-(2-(4-chlorophenyl)butan-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Base Information

Chemical Name:2-(2-(4-chlorophenyl)butan-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
CAS No.:1257661-30-5
Molecular Formula:C₁₆H₂₄BClO₂
Molecular Weight:294.629
Hs Code.:

Synonyms:2-(2-(4-chlorophenyl)butan-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

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Chemical Property of 2-(2-(4-chlorophenyl)butan-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

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Technology Process of 2-(2-(4-chlorophenyl)butan-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

There total 3 articles about 2-(2-(4-chlorophenyl)butan-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 82954-89-0
ethylboronic acid pinacol ester

: (p-ClC₆H₄)CH(Me)(carbamate)

: 1257661-30-5
2-(2-(4-chlorophenyl)butan-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Guidance literature:: With sBuLi; In diethyl ether; react. of ClC6H4CH(Me)(OCb) with sBuLi at -78°C, then EtBpin (1.5equiv.) added, heated to 20°C, 16 h; 86% ee;
DOI:10.1002/anie.201001371

Reference yield:

: C₁₆H₂₅BClO₂^(1-)*Li⁽¹⁺⁾

: 1257661-30-5
2-(2-(4-chlorophenyl)butan-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Guidance literature:: With fac-tris(2-phenylpyridinato-N,C₂')iridium(III); iodotrifluoromethane; In dimethyl sulfoxide; acetonitrile; at 20 ℃; for 1h; regioselective reaction; Inert atmosphere; Schlenk technique; Irradiation;
DOI:10.1021/jacs.9b07960

Reference yield:

: 195062-61-4
4-chlorophenylboronic acid pinacol ester

: 1257661-30-5
2-(2-(4-chlorophenyl)butan-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether / 1.08 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

2: fac-tris(2-phenylpyridinato-N,C₂')iridium(III); iodotrifluoromethane / acetonitrile; dimethyl sulfoxide / 1 h / 20 °C / Inert atmosphere; Schlenk technique; Irradiation

With fac-tris(2-phenylpyridinato-N,C₂')iridium(III); iodotrifluoromethane; In diethyl ether; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jacs.9b07960