Cyclobutanemethanol, 2-ethoxy-2-(1-methylethenyl)-, (1R,2S)- (9CI)

Base Information

Chemical Name:Cyclobutanemethanol, 2-ethoxy-2-(1-methylethenyl)-, (1R,2S)- (9CI)
CAS No.:727429-08-5
Molecular Formula:C₁₀H₁₈O₂
Molecular Weight:170.252
Hs Code.:
Mol file:727429-08-5.mol

Synonyms:Cyclobutanemethanol, 2-ethoxy-2-(1-methylethenyl)-, (1R,2S)- (9CI)

Suppliers and Price of Cyclobutanemethanol, 2-ethoxy-2-(1-methylethenyl)-, (1R,2S)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of Cyclobutanemethanol, 2-ethoxy-2-(1-methylethenyl)-, (1R,2S)- (9CI)

Chemical Property:

PSA：29.46000
LogP:1.74010

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Cyclobutanemethanol, 2-ethoxy-2-(1-methylethenyl)-, (1R,2S)- (9CI)

There total 10 articles about Cyclobutanemethanol, 2-ethoxy-2-(1-methylethenyl)-, (1R,2S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 727429-06-3
(1S,2S,5R)-1-ethoxy-2-methyl-3-oxabicyclo[3.2.0]heptane-2-carbaldehyde

: 727429-08-5
[(1R,2S)-2-ethoxy-2-isopropenyl-cyclobutyl]methanol

Guidance literature:: (1S,2S,5R)-1-ethoxy-2-methyl-3-oxabicyclo[3.2.0]heptane-2-carbaldehyde; With hydrazine dihydrochloride; hydrazine hydrate; In diethylene glycol; at 120 ℃; for 1.5h;

With potassium hydroxide; In diethylene glycol; at 210 ℃; for 1h;
DOI:10.1021/ol049696h

Reference yield:

: (R)-1-((1S,2S,5R)-1-Ethoxy-3-oxa-bicyclo[3.2.0]hept-2-yl)-ethane-1,2-diol

: 727429-08-5
[(1R,2S)-2-ethoxy-2-isopropenyl-cyclobutyl]methanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium metaperiodate; RuCl₃*3H₂O / CCl₄; H₂O; acetonitrile / 20 °C

2.1: 220 mg / diethyl ether

3.1: LDA / tetrahydrofuran; hexane / -78 - -30 °C

3.2: 72 percent / tetrahydrofuran; hexane; hexamethylphosphoric acid triamide / -78 - 20 °C

4.1: 91 percent / LiAlH₄ / diethyl ether / 0 - 20 °C

5.1: 69 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / -70 - 20 °C

6.1: hydrazine hydrate; hydrazine hydrochloride / bis-(2-hydroxy-ethyl) ether / 1.5 h / 120 °C

6.2: 54 percent / potassium hydroxide / bis-(2-hydroxy-ethyl) ether / 1 h / 210 °C

With ruthenium trichloride; sodium periodate; lithium aluminium tetrahydride; oxalyl dichloride; hydrazine hydrochloride; hydrazine hydrate; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; tetrachloromethane; diethyl ether; hexane; dichloromethane; water; acetonitrile; diethylene glycol; 5.1: Swern oxidation / 6.1: Wolf-Kishner reaction;

Reference yield:

: 727428-88-8
(2R)-2-[(1S,2S,5R)-1-ethoxy-3-oxabicyclo[3.2.0]hept-2-yl]-1,4-dioxa-spiro[4.5]decane

: 727429-08-5
[(1R,2S)-2-ethoxy-2-isopropenyl-cyclobutyl]methanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic acid / H₂O / 20 °C

2.1: sodium metaperiodate; RuCl₃*3H₂O / CCl₄; H₂O; acetonitrile / 20 °C

3.1: 220 mg / diethyl ether

4.1: LDA / tetrahydrofuran; hexane / -78 - -30 °C

4.2: 72 percent / tetrahydrofuran; hexane; hexamethylphosphoric acid triamide / -78 - 20 °C

5.1: 91 percent / LiAlH₄ / diethyl ether / 0 - 20 °C

6.1: 69 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / -70 - 20 °C

7.1: hydrazine hydrate; hydrazine hydrochloride / bis-(2-hydroxy-ethyl) ether / 1.5 h / 120 °C

7.2: 54 percent / potassium hydroxide / bis-(2-hydroxy-ethyl) ether / 1 h / 210 °C

With ruthenium trichloride; sodium periodate; lithium aluminium tetrahydride; oxalyl dichloride; hydrazine hydrochloride; hydrazine hydrate; acetic acid; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; tetrachloromethane; diethyl ether; hexane; dichloromethane; water; acetonitrile; diethylene glycol; 6.1: Swern oxidation / 7.1: Wolf-Kishner reaction;