[(2S,4aS,7R,7aR,10aS)-7-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-2-phenyl-4,4a,7,7a-tetrahydro-furo[3',2':2,3]benzo[2,1-d][1,3]dioxin-(10E)-ylidene]-acetonitrile

Base Information

Chemical Name:[(2S,4aS,7R,7aR,10aS)-7-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-2-phenyl-4,4a,7,7a-tetrahydro-furo[3',2':2,3]benzo[2,1-d][1,3]dioxin-(10E)-ylidene]-acetonitrile
CAS No.:114066-34-1
Molecular Formula:C₃₅H₃₇NO₄Si
Molecular Weight:563.769
Hs Code.:

[(2S,4aS,7R,7aR,10aS)-7-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-2-phenyl-4,4a,7,7a-tetrahydro-furo[3',2':2,3]benzo[2,1-d][1,3]dioxin-(10E)-ylidene]-acetonitrile

Synonyms:[(2S,4aS,7R,7aR,10aS)-7-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-2-phenyl-4,4a,7,7a-tetrahydro-furo[3',2':2,3]benzo[2,1-d][1,3]dioxin-(10E)-ylidene]-acetonitrile

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Chemical Property of [(2S,4aS,7R,7aR,10aS)-7-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-2-phenyl-4,4a,7,7a-tetrahydro-furo[3',2':2,3]benzo[2,1-d][1,3]dioxin-(10E)-ylidene]-acetonitrile

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Technology Process of [(2S,4aS,7R,7aR,10aS)-7-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-2-phenyl-4,4a,7,7a-tetrahydro-furo[3',2':2,3]benzo[2,1-d][1,3]dioxin-(10E)-ylidene]-acetonitrile

There total 8 articles about [(2S,4aS,7R,7aR,10aS)-7-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-2-phenyl-4,4a,7,7a-tetrahydro-furo[3',2':2,3]benzo[2,1-d][1,3]dioxin-(10E)-ylidene]-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1125-88-8
benzaldehyde dimethyl acetal

: 114066-34-1
[(2S,4aS,7R,7aR,10aS)-7-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-2-phenyl-4,4a,7,7a-tetrahydro-furo[3',2':2,3]benzo[2,1-d][1,3]dioxin-(10E)-ylidene]-acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: p-TsOH / CH₂Cl₂

2: Jones reagent / acetone / 0.08 h / 0 °C

3: sodium borohydride / methanol / 0.17 h

4: 95 percent / imidazole, DMAP / dimethylformamide / 48 h

With 1H-imidazole; dmap; sodium tetrahydroborate; jones reagent; toluene-4-sulfonic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4039(00)96345-7

Reference yield:

: 114066-31-8
[(3aS,4S,7S,7aR)-3a,7-Dihydroxy-4-hydroxymethyl-6-methyl-3a,4,7,7a-tetrahydro-benzofuran-(3E)-ylidene]-acetonitrile

: 114066-34-1
[(2S,4aS,7R,7aR,10aS)-7-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-2-phenyl-4,4a,7,7a-tetrahydro-furo[3',2':2,3]benzo[2,1-d][1,3]dioxin-(10E)-ylidene]-acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: p-TsOH / CH₂Cl₂

2: Jones reagent / acetone / 0.08 h / 0 °C

3: sodium borohydride / methanol / 0.17 h

4: 95 percent / imidazole, DMAP / dimethylformamide / 48 h

With 1H-imidazole; dmap; sodium tetrahydroborate; jones reagent; toluene-4-sulfonic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4039(00)96345-7

Reference yield:

: 114066-27-2
(3aR,4S,7S,7aR)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-7-hydroxy-6-methyl-3a-trimethylsilanyloxy-3a,4,7,7a-tetrahydro-benzofuran-3-one

: 114066-34-1
[(2S,4aS,7R,7aR,10aS)-7-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-2-phenyl-4,4a,7,7a-tetrahydro-furo[3',2':2,3]benzo[2,1-d][1,3]dioxin-(10E)-ylidene]-acetonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / toluene / 12 h / 110 °C / Heating

2: 1percent HF / acetonitrile / 0.5 h

3: p-TsOH / CH₂Cl₂

4: Jones reagent / acetone / 0.08 h / 0 °C

5: sodium borohydride / methanol / 0.17 h

6: 95 percent / imidazole, DMAP / dimethylformamide / 48 h

With 1H-imidazole; dmap; sodium tetrahydroborate; jones reagent; hydrogen fluoride; toluene-4-sulfonic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;
DOI:10.1016/S0040-4039(00)96345-7