1-Bromospiro[2.2]pentane

Base Information

• Chemical Name: 1-Bromospiro[2.2]pentane
• CAS No.: 75522-03-1
• Molecular Formula: C5H7 Br
• Molecular Weight: 147.015
• Hs Code.: 2903890090
• European Community (EC) Number: 819-487-3
• DSSTox Substance ID: DTXSID90445284
• Nikkaji Number: J1.216.182D
• Mol file: 75522-03-1.mol

Synonyms:1-bromospiro[2.2]pentane;75522-03-1;2-bromospiro[2.2]pentane;DTXSID90445284;AKOS022173167;AG-H-01017;EN300-91986

Chemical Property of 1-Bromospiro[2.2]pentane

Chemical Property:

• PSA: 0.00000
• LogP: 1.93380
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 0
• Exact Mass: 145.97311
• Heavy Atom Count: 6
• Complexity: 83.9

Purity/Quality:

98% ^*data from raw suppliers

2-bromospiro[2.2]pentane >96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC12CC2Br

Technology Process of 1-Bromospiro[2.2]pentane

There total 1 articles about 1-Bromospiro[2.2]pentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

1,1-dibromospiro[2.2]pentane (64149-45-7) → spiropentyl bromide (75522-03-1)

Guidance literature:

With dibutylstannane; at 20 - 25 ℃; for 0.25h;

Reference yield: 55.0%

spiropentyl bromide (75522-03-1) + tert-butyl-acetyloxydiphenylmethyleneaminoacetate (176965-32-5) → N-(diphenylmethylene)glycine tert-butyl ester (81477-94-3) + tert-butyl N-(diphenylmethylene)-α-spiropentylglycinate

Guidance literature:

spiropentyl bromide; With tert.-butyl lithium; In diethyl ether; pentane; at -78 ℃; for 1h;

In tetrahydrofuran; at -110 - -40 ℃; for 20h;

tert-butyl-acetyloxydiphenylmethyleneaminoacetate; In tetrahydrofuran; at -10 ℃; for 6.5h;

Reference yield: 4.0%

spiropentyl bromide (75522-03-1) → Cyclopropylacetylene (6746-94-7) + spiropentene (661-39-2)

Guidance literature:

With potassium tert-butylate; In dimethyl sulfoxide; at 90 ℃; under 80 Torr; Title compound not separated from byproducts;

upstream raw materials:

1,1-dibromospiro[2.2]pentane

Downstream raw materials:

Cyclopropylacetylene

spiropentene

N-(diphenylmethylene)glycine tert-butyl ester

Refernces