d9-1-(3-bromo-2-fluoro-phenoxymethyl)-7-oxa-bicyclo[2.2.1]heptane

Base Information

• Chemical Name: d9-1-(3-bromo-2-fluoro-phenoxymethyl)-7-oxa-bicyclo[2.2.1]heptane
• CAS No.: 1398923-83-5
• Molecular Formula: C₁₃H₁₄BrFO₂
• Molecular Weight: 310.084
• Mol file: 1398923-83-5.mol

Synonyms:d9-1-(3-bromo-2-fluoro-phenoxymethyl)-7-oxa-bicyclo[2.2.1]heptane

Chemical Property of d9-1-(3-bromo-2-fluoro-phenoxymethyl)-7-oxa-bicyclo[2.2.1]heptane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of d9-1-(3-bromo-2-fluoro-phenoxymethyl)-7-oxa-bicyclo[2.2.1]heptane

There total 3 articles about d9-1-(3-bromo-2-fluoro-phenoxymethyl)-7-oxa-bicyclo[2.2.1]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromo-2-fluoro-phenol (156682-53-0) + d9-1-iodomethyl-7-oxa-bicyclo[2.2.1]heptane (1272667-94-3) → d9-1-(3-bromo-2-fluoro-phenoxymethyl)-7-oxa-bicyclo[2.2.1]heptane (1398923-83-5)

Guidance literature:

With sodium hydride; In acetonitrile; at 150 ℃; for 48h; sealed tube;

Reference yield:

d9-4-methylene-cyclohexanol (1272667-95-4) → d9-1-(3-bromo-2-fluoro-phenoxymethyl)-7-oxa-bicyclo[2.2.1]heptane (1398923-83-5)

Guidance literature:

Multi-step reaction with 2 steps

1: iodine; sodium carbonate / acetonitrile / 1 h / 20 °C / Darkness

2: sodium hydride / acetonitrile / 48 h / 150 °C / sealed tube

With iodine; sodium hydride; sodium carbonate; In acetonitrile;

Reference yield:

d8-4-methylene-cyclohexanone (1272667-96-5) → d9-1-(3-bromo-2-fluoro-phenoxymethyl)-7-oxa-bicyclo[2.2.1]heptane (1398923-83-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium borodeuteride / tetrahydrofuran / 1 h / 0 - 20 °C

2: iodine; sodium carbonate / acetonitrile / 1 h / 20 °C / Darkness

3: sodium hydride / acetonitrile / 48 h / 150 °C / sealed tube

With sodium borodeuteride; iodine; sodium hydride; sodium carbonate; In tetrahydrofuran; acetonitrile;

upstream raw materials:

3-bromo-2-fluoro-phenol

d9-1-iodomethyl-7-oxa-bicyclo[2.2.1]heptane

d9-4-methylene-cyclohexanol

d8-4-methylene-cyclohexanone

Downstream raw materials:

d9-1-[2-fluoro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxymethyl]-7-oxa-bicyclo[2.2.1]heptane