1,3-DI(Benzyloxymethyl)-5-fluorouracil

Base Information

• Chemical Name: 1,3-DI(Benzyloxymethyl)-5-fluorouracil
• CAS No.: 75500-03-7
• Molecular Formula: C20H19 F N2 O4
• Molecular Weight: 370.38
• DSSTox Substance ID: DTXSID90515279
• Wikidata: Q82376071
• Mol file: 75500-03-7.mol

Synonyms:1,3-DI(BENZYLOXYMETHYL)-5-FLUOROURACIL;75500-03-7;5-fluoro-1,3-bis(phenylmethoxymethyl)pyrimidine-2,4-dione;SCHEMBL21190332;DTXSID90515279;FT-0666449;1,3-Bis[(benzyloxy)methyl]-5-fluoropyrimidine-2,4(1H,3H)-dione

Chemical Property of 1,3-DI(Benzyloxymethyl)-5-fluorouracil

Chemical Property:

• Vapor Pressure: 6.26E-09mmHg at 25°C
• Refractive Index: 1.617
• Boiling Point: 467.9°C at 760 mmHg
• Flash Point: 236.8°C
• PSA: 62.46000
• Density: 1.32g/cm³
• LogP: 2.49770
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform, Methanol
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 8
• Exact Mass: 370.13288525
• Heavy Atom Count: 27
• Complexity: 542

Purity/Quality:

99% ^*data from raw suppliers

1,3-Di(benzyloxymethyl)-5-fluorouracil ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COCN2C=C(C(=O)N(C2=O)COCC3=CC=CC=C3)F
• Uses: 1,3-Di(benzyloxymethyl)-5-fluorouracil (cas# 75500-03-7) is a compound useful in organic synthesis.

Technology Process of 1,3-DI(Benzyloxymethyl)-5-fluorouracil

There total 1 articles about 1,3-DI(Benzyloxymethyl)-5-fluorouracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-fluorouracil (51-21-8) + Benzyloxymethyl chloride (3587-60-8) → 1,3-bis-((benzyloxy)methyl)-5-fluoropyrimidine-2,4(1H,3H)-dione (75500-03-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1016/S0040-4039(01)83925-3

Reference yield: 60.0%

1,3-bis-((benzyloxy)methyl)-5-fluoropyrimidine-2,4(1H,3H)-dione (75500-03-7) → 5-fluorouracil (51-21-8)

Guidance literature:

With boron tribromide; In benzene; for 1h; Ambient temperature;

DOI:10.1016/S0040-4039(01)83926-5

Reference yield:

1,3-bis-((benzyloxy)methyl)-5-fluoropyrimidine-2,4(1H,3H)-dione (75500-03-7) → 1,3-Bis-benzyloxymethyl-5-fluoro-dihydro-pyrimidine-2,4-dione (75500-13-9)

Guidance literature:

With water; L-Selectride; Yield given. Multistep reaction; 1.) DMF, dry ice-acetone bath, 5-10 min;

DOI:10.1016/S0040-4039(01)83925-3

upstream raw materials:

5-fluorouracil

Benzyloxymethyl chloride

Downstream raw materials:

5-fluorouracil

1,3-Bis-benzyloxymethyl-5-fluoro-dihydro-pyrimidine-2,4-dione

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 75500-03-7 1,3-Di(benzyloxymethyl)-5-fluorouracil

Send

Send

Metric Ton KG G Pound L ML

Send

Send